SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2on5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HTQ_A_ZMRA472_1 (NEURAMINIDASE)	2on5	NA GLUTATHIONE S-TRANSFERASE 2 (Necator americanus)	5 / 12	ARG A 33 GLU A 16 ALA A 169 GLU A 162 ARG A 189	None	1.42A	2htqA-2on5A: undetectable	2htqA-2on5A: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_A_KLNA1500_1 (CYTOCHROME P450 3A4)	2on5	NA GLUTATHIONE S-TRANSFERASE 2 (Necator americanus)	5 / 11	SER A 72 LEU A 194 ILE A 21 ALA A 25 GLU A 84	None None None EDO A 428 (-4.3A) None	1.13A	2v0mA-2on5A: 1.1	2v0mA-2on5A: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_B_KLNB1498_1 (CYTOCHROME P450 3A4)	2on5	NA GLUTATHIONE S-TRANSFERASE 2 (Necator americanus)	5 / 9	SER A 72 LEU A 194 ILE A 21 ALA A 25 GLU A 84	None None None EDO A 428 (-4.3A) None	1.27A	2v0mB-2on5A: undetectable	2v0mB-2on5A: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_D_KLND1498_1 (CYTOCHROME P450 3A4)	2on5	NA GLUTATHIONE S-TRANSFERASE 2 (Necator americanus)	5 / 11	SER A 72 LEU A 194 ILE A 21 ALA A 25 GLU A 84	None None None EDO A 428 (-4.3A) None	1.22A	2v0mD-2on5A: undetectable	2v0mD-2on5A: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ADS_B_IMNB3_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2on5	NA GLUTATHIONE S-TRANSFERASE 2 (Necator americanus)	5 / 12	GLY A 79 SER A 72 ALA A 68 ILE A 21 LEU A 158	None None EDO A 425 ( 3.8A) None None	1.21A	3adsB-2on5A: undetectable	3adsB-2on5A: 23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXC_A_ROCA401_2 (PROTEASE)	2on5	NA GLUTATHIONE S-TRANSFERASE 2 (Necator americanus)	3 / 3	ARG A 189 LEU A 194 THR A 200	None	0.81A	3oxcA-2on5A: undetectable	3oxcA-2on5A: 19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QLH_A_T27A555_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	2on5	NA GLUTATHIONE S-TRANSFERASE 2 (Necator americanus)	5 / 12	PRO A 52 LEU A 6 TYR A 8 PRO A 202 TYR A 29	GSH A 999 ( 4.6A) None GSH A 999 (-4.9A) None EDO A 427 (-3.6A)	1.40A	3qlhA-2on5A: 1.3	3qlhA-2on5A: 16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XUM_B_IMNB501_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	2on5	NA GLUTATHIONE S-TRANSFERASE 2 (Necator americanus)	5 / 11	GLY A 79 SER A 72 ALA A 68 ILE A 21 LEU A 158	None None EDO A 425 ( 3.8A) None None	1.19A	4xumB-2on5A: undetectable	4xumB-2on5A: 24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F6S_A_CXQA507_1 (ENVELOPE GLYCOPROTEIN,ENVELOP E GLYCOPROTEIN,GP1 ENVELOPE GLYCOPROTEIN)	2on5	NA GLUTATHIONE S-TRANSFERASE 2 (Necator americanus)	4 / 5	ALA A 23 TYR A 29 GLN A 20 ILE A 18	None EDO A 427 (-3.6A) None EDO A 425 (-4.7A)	1.21A	6f6sA-2on5A: undetectable 6f6sB-2on5A: undetectable	6f6sA-2on5A: 18.92 6f6sB-2on5A: 15.69

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2HTQ_A_ZMRA472_1","NEURAMINIDASE","2on5","NA GLUTATHIONE S-TRANSFERASE 2","Necator americanus",5,"ARG A  33;GLU A  16;ALA A 169;GLU A 162;ARG A 189","None","1.42A","2htqA-2on5A:undetectable","2htqA-2on5A:19.28"],["2V0M_A_KLNA1500_1","CYTOCHROME P450 3A4","2on5","NA GLUTATHIONE S-TRANSFERASE 2","Necator americanus",5,"SER A  72;LEU A 194;ILE A  21;ALA A  25;GLU A  84","None;None;None;EDO A 428 (-4.3A);None","1.13A","2v0mA-2on5A:1.1","2v0mA-2on5A:20.14"],["2V0M_B_KLNB1498_1","CYTOCHROME P450 3A4","2on5","NA GLUTATHIONE S-TRANSFERASE 2","Necator americanus",5,"SER A  72;LEU A 194;ILE A  21;ALA A  25;GLU A  84","None;None;None;EDO A 428 (-4.3A);None","1.27A","2v0mB-2on5A:undetectable","2v0mB-2on5A:20.14"],["2V0M_D_KLND1498_1","CYTOCHROME P450 3A4","2on5","NA GLUTATHIONE S-TRANSFERASE 2","Necator americanus",5,"SER A  72;LEU A 194;ILE A  21;ALA A  25;GLU A  84","None;None;None;EDO A 428 (-4.3A);None","1.22A","2v0mD-2on5A:undetectable","2v0mD-2on5A:20.14"],["3ADS_B_IMNB3_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","2on5","NA GLUTATHIONE S-TRANSFERASE 2","Necator americanus",5,"GLY A  79;SER A  72;ALA A  68;ILE A  21;LEU A 158","None;None;EDO A 425 ( 3.8A);None;None","1.21A","3adsB-2on5A:undetectable","3adsB-2on5A:23.71"],["3OXC_A_ROCA401_2","PROTEASE","2on5","NA GLUTATHIONE S-TRANSFERASE 2","Necator americanus",3,"ARG A 189;LEU A 194;THR A 200","None","0.81A","3oxcA-2on5A:undetectable","3oxcA-2on5A:19.39"],["3QLH_A_T27A555_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","2on5","NA GLUTATHIONE S-TRANSFERASE 2","Necator americanus",5,"PRO A  52;LEU A   6;TYR A   8;PRO A 202;TYR A  29","GSH A 999 ( 4.6A);None;GSH A 999 (-4.9A);None;EDO A 427 (-3.6A)","1.40A","3qlhA-2on5A:1.3","3qlhA-2on5A:16.97"],["4XUM_B_IMNB501_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","2on5","NA GLUTATHIONE S-TRANSFERASE 2","Necator americanus",5,"GLY A  79;SER A  72;ALA A  68;ILE A  21;LEU A 158","None;None;EDO A 425 ( 3.8A);None;None","1.19A","4xumB-2on5A:undetectable","4xumB-2on5A:24.11"],["6F6S_A_CXQA507_1","ENVELOPE GLYCOPROTEIN,ENVELOPE GLYCOPROTEIN,GP1;ENVELOPE GLYCOPROTEIN","2on5","NA GLUTATHIONE S-TRANSFERASE 2","Necator americanus",4,"ALA A  23;TYR A  29;GLN A  20;ILE A  18","None;EDO A 427 (-3.6A);None;EDO A 425 (-4.7A)","1.21A","6f6sA-2on5A:undetectable;6f6sB-2on5A:undetectable","6f6sA-2on5A:18.92;6f6sB-2on5A:15.69"]]