SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ond'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2ond CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		4 / 7 VAL A 413
ALA A 449
PHE A 398
THR A 375
 None
 0.99A 2q6oA-2ondA:
undetectable		 2q6oA-2ondA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2ond CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		3 / 3 HIS A 360
GLY A 394
ILE A 397
 None
 0.53A 4k50A-2ondA:
undetectable		 4k50A-2ondA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2ond CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		3 / 3 HIS A 360
GLY A 394
ILE A 397
 None
 0.56A 4k50I-2ondA:
2.3		 4k50I-2ondA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 2ond CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		3 / 3 GLU A 259
TRP A 258
LYS A 274
 None
 1.05A 4k7aA-2ondA:
undetectable		 4k7aA-2ondA:
20.25