SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oo3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		5 / 11 PHE A 104
LEU A 259
VAL A 255
PHE A  79
VAL A  68
 None
 1.30A 1q23L-2oo3A:
undetectable		 1q23L-2oo3A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		3 / 3 THR A  23
GLU A 251
HIS A  31
 None
 0.74A 1xwfA-2oo3A:
2.8		 1xwfA-2oo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		3 / 3 THR A  23
GLU A 251
HIS A  31
 None
 0.75A 1xwfB-2oo3A:
4.9		 1xwfB-2oo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		3 / 3 THR A  23
GLU A 251
HIS A  31
 None
 0.73A 1xwfC-2oo3A:
4.6		 1xwfC-2oo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		3 / 3 THR A  23
GLU A 251
HIS A  31
 None
 0.72A 1xwfD-2oo3A:
2.8		 1xwfD-2oo3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		3 / 3 ASP A 113
VAL A 138
PRO A 132
 None
 0.53A 2avvA-2oo3A:
undetectable		 2avvA-2oo3A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		5 / 10 ALA A 105
ILE A 106
GLY A 100
ASP A  15
PHE A 163
 None
 1.18A 2b17A-2oo3A:
undetectable		 2b17A-2oo3A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		3 / 3 SER A 101
GLU A 119
ASP A 165
 None
 0.35A 2zthA-2oo3A:
12.6		 2zthA-2oo3A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		3 / 3 SER A 101
GLU A 119
ASP A 165
 None
 0.18A 3bwmA-2oo3A:
11.5		 3bwmA-2oo3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		3 / 3 SER A 101
GLU A 119
ASP A 165
 None
 0.27A 3bwyA-2oo3A:
11.7		 3bwyA-2oo3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		4 / 7 LEU A 256
GLU A 251
PRO A 249
ILE A 252
 None
 0.82A 3s56B-2oo3A:
undetectable		 3s56B-2oo3A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		4 / 6 GLY A  44
GLU A 119
ASP A 144
ASP A 165
 None
 1.06A 3vywC-2oo3A:
6.7		 3vywC-2oo3A:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		7 / 12 LYS A  18
HIS A  42
GLY A  44
GLY A 100
LEU A 120
HIS A 121
GLY A 145
 None
 0.71A 4blvA-2oo3A:
38.9		 4blvA-2oo3A:
38.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		5 / 6 HIS A  19
SER A 101
GLU A 119
ASP A 144
ASP A 165
 None
 0.70A 4blvA-2oo3A:
38.9		 4blvA-2oo3A:
38.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		11 / 12 LYS A  18
HIS A  19
HIS A  42
GLY A  44
TYR A  48
GLY A 100
SER A 101
LEU A 120
HIS A 121
GLY A 145
ASP A 165
 None
 0.71A 4blvB-2oo3A:
38.2		 4blvB-2oo3A:
38.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		5 / 12 GLY A  46
GLY A 100
LEU A 120
ASP A 144
GLY A 145
 None
 0.85A 4fp9D-2oo3A:
9.1		 4fp9D-2oo3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		5 / 12 GLY A  46
GLY A 100
LEU A 120
ASP A 144
GLY A 145
 None
 0.83A 4fzvA-2oo3A:
8.8		 4fzvA-2oo3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		6 / 12 TYR A 262
LEU A 259
ILE A  65
TYR A  82
ILE A  20
PRO A  76
 None
None
None
None
None
SO4  A 303 (-4.5A)
 1.31A 4odrA-2oo3A:
undetectable
4odrB-2oo3A:
undetectable		 4odrA-2oo3A:
15.85
4odrB-2oo3A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		6 / 12 TYR A 262
LEU A 259
TYR A  82
ILE A  20
PHE A 263
PRO A  76
 None
None
None
None
None
SO4  A 303 (-4.5A)
 1.28A 4odrA-2oo3A:
undetectable
4odrB-2oo3A:
undetectable		 4odrA-2oo3A:
15.85
4odrB-2oo3A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		3 / 3 SER A 101
GLU A 119
ASP A 165
 None
 0.25A 4xudA-2oo3A:
9.4		 4xudA-2oo3A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		3 / 3 PHE A  13
ASP A  15
LEU A  70
 None
 0.72A 5uhbC-2oo3A:
undetectable		 5uhbC-2oo3A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		3 / 3 PHE A  13
ASP A  15
LEU A  70
 None
 0.76A 5uhcC-2oo3A:
undetectable		 5uhcC-2oo3A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2oo3 PROTEIN INVOLVED IN
CATABOLISM OF
EXTERNAL DNA
(Legionella
pneumophila) 		4 / 6 SER A 101
GLU A 119
ASP A 144
ASP A 165
 None
 0.74A 5zw4A-2oo3A:
11.4		 5zw4A-2oo3A:
22.56