SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oo4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2
(Homo
sapiens) 		5 / 9 LEU A1625
ALA A1646
GLY A1570
LEU A1659
LEU A1650
 None
None
GOL  A7007 ( 3.7A)
None
None
 1.15A 1nr6A-2oo4A:
undetectable		 1nr6A-2oo4A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2
(Homo
sapiens) 		3 / 3 ASP A1454
GLU A1617
TYR A1592
 CA  A5001 (-3.4A)
None
None
 0.45A 1wsvA-2oo4A:
undetectable		 1wsvA-2oo4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2
(Homo
sapiens) 		3 / 3 GLY A1453
GLU A1460
ASP A1454
 None
None
CA  A5001 (-3.4A)
 0.68A 2b25B-2oo4A:
undetectable		 2b25B-2oo4A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2
(Homo
sapiens) 		5 / 11 SER A1660
ASN A1493
THR A1658
HIS A1653
PHE A1494
 None
 1.45A 2hmaA-2oo4A:
undetectable		 2hmaA-2oo4A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2
(Homo
sapiens) 		4 / 4 LEU A1572
ILE A1549
GLY A1570
PHE A1565
 None
None
GOL  A7007 ( 3.7A)
None
 1.07A 4dc3A-2oo4A:
undetectable		 4dc3A-2oo4A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2
(Homo
sapiens) 		5 / 8 THR A1658
LEU A1649
VAL A1666
LEU A1457
GLY A1657
 None
 1.33A 4r3aA-2oo4A:
undetectable		 4r3aA-2oo4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2
(Homo
sapiens) 		3 / 3 SER A1621
ALA A1619
VAL A1618
 None
 0.56A 4x20C-2oo4A:
undetectable		 4x20C-2oo4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2
(Homo
sapiens) 		5 / 10 LEU A1558
ALA A1562
LEU A1566
LEU A1569
LEU A1587
 None
GOL  A7008 ( 3.8A)
GOL  A7007 (-4.7A)
None
GOL  A7001 (-4.9A)
 1.35A 5hyrA-2oo4A:
undetectable		 5hyrA-2oo4A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2
(Homo
sapiens) 		5 / 12 GLU A1525
SER A1636
THR A1643
GLY A1570
LEU A1573
 ZN  A6001 (-2.3A)
ZN  A6001 ( 4.5A)
None
GOL  A7007 ( 3.7A)
None
 1.15A 5ogcB-2oo4A:
undetectable		 5ogcB-2oo4A:
18.44