SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ooe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE509_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		4 / 6 ASP A  82
GLU A  75
TYR A  71
LYS A  83
 None
 1.37A 1yc2A-2ooeA:
0.0
1yc2B-2ooeA:
0.0
1yc2E-2ooeA:
0.0		 1yc2A-2ooeA:
19.05
1yc2B-2ooeA:
19.05
1yc2E-2ooeA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		4 / 7 VAL A 413
ALA A 449
PHE A 398
THR A 375
 None
 1.04A 2q6oA-2ooeA:
undetectable		 2q6oA-2ooeA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		4 / 9 ILE A 293
ALA A 246
VAL A 249
LYS A 254
 None
 1.03A 2vufB-2ooeA:
undetectable		 2vufB-2ooeA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		5 / 12 TYR A  54
LEU A  57
PHE A  67
ARG A  56
GLU A  22
 None
 1.27A 4fiaA-2ooeA:
undetectable		 4fiaA-2ooeA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		5 / 12 TYR A  54
LEU A  57
PHE A  67
ARG A  56
GLU A  22
 None
 1.27A 4fiaA-2ooeA:
undetectable		 4fiaA-2ooeA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		3 / 3 HIS A 360
GLY A 394
ILE A 397
 None
 0.43A 4k50A-2ooeA:
1.1		 4k50A-2ooeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		3 / 3 HIS A 360
GLY A 394
ILE A 397
 None
 0.45A 4k50I-2ooeA:
1.9		 4k50I-2ooeA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		5 / 12 GLY A 175
TYR A 172
TYR A 146
TYR A 213
ALA A 216
 None
 1.37A 4ymgA-2ooeA:
undetectable		 4ymgA-2ooeA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		4 / 5 ALA A 297
TYR A 300
GLY A 175
LEU A 271
 None
 0.88A 5eslA-2ooeA:
undetectable		 5eslA-2ooeA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		5 / 12 LEU A  87
PHE A  67
GLY A  65
LEU A 335
LEU A  32
 None
 1.17A 5y2tA-2ooeA:
undetectable		 5y2tA-2ooeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT
(Mus
musculus) 		4 / 6 GLN A 244
GLU A 245
TRP A 252
ALA A 234
 None
 1.16A 6f6jC-2ooeA:
undetectable
6f6jD-2ooeA:
undetectable		 6f6jC-2ooeA:
20.76
6f6jD-2ooeA:
20.76