SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ook'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2ook HYPOTHETICAL PROTEIN
(Shewanella
frigidimarina) 		5 / 11 LEU A 124
LEU A 121
ALA A 120
GLU A 117
LEU A  90
 None
 1.22A 1g50A-2ookA:
undetectable		 1g50A-2ookA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ook HYPOTHETICAL PROTEIN
(Shewanella
frigidimarina) 		4 / 5 PHE A 106
LEU A  74
PHE A  84
SER A  46
 None
 1.14A 1wrlC-2ookA:
undetectable		 1wrlC-2ookA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ook HYPOTHETICAL PROTEIN
(Shewanella
frigidimarina) 		5 / 12 LEU A  76
LEU A  23
VAL A  21
SER A  46
GLY A  43
 None
 1.13A 2vmyB-2ookA:
undetectable		 2vmyB-2ookA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2ook HYPOTHETICAL PROTEIN
(Shewanella
frigidimarina) 		5 / 12 LEU A 124
LEU A 121
ALA A 120
GLU A 117
LEU A  90
 None
 1.13A 3olsA-2ookA:
undetectable		 3olsA-2ookA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 2ook HYPOTHETICAL PROTEIN
(Shewanella
frigidimarina) 		4 / 4 TRP A 105
LEU A  23
LEU A  41
THR A  38
 None
 1.43A 4bboD-2ookA:
undetectable		 4bboD-2ookA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2ook HYPOTHETICAL PROTEIN
(Shewanella
frigidimarina) 		4 / 8 ILE A  10
LEU A  41
LEU A  76
LEU A  55
 None
 0.80A 4zvcA-2ookA:
undetectable
4zvcB-2ookA:
undetectable		 4zvcA-2ookA:
19.01
4zvcB-2ookA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2ook HYPOTHETICAL PROTEIN
(Shewanella
frigidimarina) 		4 / 8 LEU A  76
LEU A  55
ILE A  10
LEU A  41
 None
 0.80A 4zvcA-2ookA:
undetectable
4zvcB-2ookA:
undetectable		 4zvcA-2ookA:
19.01
4zvcB-2ookA:
19.01