SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ool'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		4 / 7 ARG A 175
ASP A 199
TRP A 167
ARG A 155
 None
 1.48A 1ceaB-2oolA:
undetectable		 1ceaB-2oolA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		4 / 6 TYR A 308
PRO A 229
GLU A 315
ARG A 311
 None
 1.37A 1oniA-2oolA:
undetectable
1oniC-2oolA:
undetectable		 1oniA-2oolA:
17.12
1oniC-2oolA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		5 / 12 ILE A  55
VAL A  48
VAL A 129
LEU A  90
THR A  91
 None
 0.98A 2aw1A-2oolA:
undetectable		 2aw1A-2oolA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		4 / 8 ASP A 216
TYR A 185
GLY A 193
PRO A 213
 LBV  A 400 (-4.0A)
LBV  A 400 ( 4.6A)
None
None
 1.00A 2ys6A-2oolA:
undetectable		 2ys6A-2oolA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		5 / 12 MET A 273
ILE A 296
VAL A 184
VAL A 173
ARG A 231
 LBV  A 400 ( 4.6A)
None
None
None
None
 1.23A 3fpjB-2oolA:
undetectable		 3fpjB-2oolA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		4 / 6 ILE A 128
VAL A  47
LEU A  45
LEU A 257
 None
 0.89A 3kp6A-2oolA:
undetectable
3kp6B-2oolA:
undetectable		 3kp6A-2oolA:
17.72
3kp6B-2oolA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		4 / 6 VAL A  62
LEU A  73
ILE A  55
VAL A 109
 None
 0.67A 4a9kA-2oolA:
undetectable		 4a9kA-2oolA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 294
GLN A 186
LEU A 321
GLU A 329
ILE A 196
 None
 1.29A 4pb1A-2oolA:
undetectable		 4pb1A-2oolA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 294
GLN A 186
LEU A 321
GLU A 329
ILE A 196
 None
 1.25A 4pd9A-2oolA:
undetectable		 4pd9A-2oolA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		5 / 12 ILE A 102
VAL A  48
LEU A 122
LEU A  82
LEU A 107
 None
 1.10A 4qzuC-2oolA:
undetectable		 4qzuC-2oolA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		4 / 6 CYH A 166
ILE A 168
GLN A 324
ILE A 286
 None
 1.12A 4w5tA-2oolA:
undetectable		 4w5tA-2oolA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		5 / 11 ASP A 126
ALA A  56
VAL A  47
GLY A 252
SER A 127
 None
 1.19A 4xnxA-2oolA:
undetectable		 4xnxA-2oolA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		4 / 6 LEU A 107
VAL A 109
THR A 111
LEU A 131
 None
 0.99A 5tudD-2oolA:
2.1		 5tudD-2oolA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		5 / 12 VAL A  62
LEU A 133
VAL A  58
SER A  49
ILE A  55
 None
 0.94A 5vopA-2oolA:
undetectable		 5vopA-2oolA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2ool SENSOR PROTEIN
(Rhodopseudomonas
palustris) 		4 / 6 SER A 139
ARG A 174
ARG A 304
ASP A 199
 None
 1.30A 5zw4A-2oolA:
undetectable		 5zw4A-2oolA:
21.57