SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ooq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		4 / 6 GLN A1154
CYH A1106
VAL A1008
GLY A1114
 None
 1.20A 1ekjC-2ooqA:
undetectable
1ekjD-2ooqA:
undetectable		 1ekjC-2ooqA:
22.30
1ekjD-2ooqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		4 / 6 CYH A1106
VAL A1008
GLY A1114
GLN A1154
 None
 1.18A 1ekjC-2ooqA:
undetectable
1ekjD-2ooqA:
undetectable		 1ekjC-2ooqA:
22.30
1ekjD-2ooqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		4 / 8 PHE A1157
ILE A1119
PRO A1078
LEU A1084
 None
 0.94A 1hmyA-2ooqA:
undetectable		 1hmyA-2ooqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		4 / 8 ASP A1120
PHE A1116
LEU A1084
THR A1113
 None
 1.11A 1rmtD-2ooqA:
undetectable		 1rmtD-2ooqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		4 / 6 ARG A 950
ASP A 947
THR A 928
ASP A 963
 None
 1.14A 2j2pE-2ooqA:
undetectable
2j2pF-2ooqA:
undetectable		 2j2pE-2ooqA:
21.31
2j2pF-2ooqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		4 / 7 LEU A1043
ARG A1089
GLU A1063
ARG A1065
 None
None
None
B3P  A 301 (-4.3A)
 1.07A 2jn3A-2ooqA:
undetectable		 2jn3A-2ooqA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		5 / 12 LEU A1085
ILE A1102
PRO A1078
VAL A1008
TRP A1072
 None
 1.21A 2pnjB-2ooqA:
2.0		 2pnjB-2ooqA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		3 / 3 ASN A 938
ASN A 966
ARG A1145
 None
 0.75A 2rlcA-2ooqA:
undetectable		 2rlcA-2ooqA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		3 / 3 ARG A 950
ASP A 992
ASN A 934
 None
 0.81A 2zzmA-2ooqA:
undetectable		 2zzmA-2ooqA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		5 / 12 VAL A1104
ALA A 981
PHE A1087
PHE A1116
GLY A1114
 None
 1.20A 4mm6A-2ooqA:
undetectable		 4mm6A-2ooqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		4 / 8 SER A 945
SER A 949
HIS A 948
ILE A 970
 None
 1.16A 4ms4A-2ooqA:
2.5		 4ms4A-2ooqA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		5 / 9 ILE A1048
VAL A1053
LEU A1064
ILE A 997
PHE A1067
 B3P  A 301 ( 3.7A)
None
None
None
None
 1.31A 4r38C-2ooqA:
undetectable		 4r38C-2ooqA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		4 / 7 ASP A1124
ASP A1120
TYR A 979
GLY A 972
 None
 0.97A 5hwaA-2ooqA:
undetectable		 5hwaA-2ooqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens) 		3 / 3 THR A1009
GLU A1013
HIS A1075
 None
 0.93A 5xioA-2ooqA:
undetectable		 5xioA-2ooqA:
19.43