SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oor'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Rhodospirillum
rubrum) 		4 / 6 MET C 185
LEU C 161
PHE C 126
MET C  43
 None
 1.19A 1x8vA-2oorC:
undetectable		 1x8vA-2oorC:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Rhodospirillum
rubrum) 		3 / 3 SER C 169
HIS C  85
ASP C 153
 None
 0.75A 2wa2B-2oorC:
undetectable		 2wa2B-2oorC:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Rhodospirillum
rubrum) 		5 / 12 GLY C 129
THR C 134
ILE C 163
ASP C 190
ALA C 191
 TXP  C 400 (-3.9A)
None
None
TXP  C 400 (-3.7A)
TXP  C 400 (-3.5A)
 1.10A 3nvkI-2oorC:
3.7		 3nvkI-2oorC:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Rhodospirillum
rubrum) 		4 / 7 PHE C  41
ASN C  45
THR C 159
LEU C 161
 None
 1.03A 3t3sC-2oorC:
undetectable		 3t3sC-2oorC:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Rhodospirillum
rubrum) 		3 / 3 ARG C 181
GLU C 155
ASN C 183
 None
 0.86A 4ip7D-2oorC:
undetectable		 4ip7D-2oorC:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Rhodospirillum
rubrum) 		5 / 12 GLY C  56
TYR C 171
ILE C 163
ALA C  62
ASP C 190
 TXP  C 400 (-3.4A)
TXP  C 400 (-3.9A)
None
None
TXP  C 400 (-3.7A)
 0.97A 5kvaA-2oorC:
undetectable		 5kvaA-2oorC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2oor NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA
(Rhodospirillum
rubrum) 		5 / 12 GLY C  56
TYR C 171
ILE C 163
ALA C  62
ASP C 190
 TXP  C 400 (-3.4A)
TXP  C 400 (-3.9A)
None
None
TXP  C 400 (-3.7A)
 0.95A 5kvaB-2oorC:
undetectable		 5kvaB-2oorC:
21.29