SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		5 / 12 THR G 191
GLY G 302
GLU G 301
VAL G 293
ASN G 311
 AMP  G 401 (-3.7A)
None
None
None
None
 1.23A 1n2xA-2ooxG:
undetectable		 1n2xA-2ooxG:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		4 / 5 MET G 200
ALA G 198
TYR G 232
ILE G 221
 None
 0.93A 1upfA-2ooxG:
undetectable		 1upfA-2ooxG:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		4 / 5 MET G 200
ALA G 198
TYR G 232
ILE G 221
 None
 0.92A 1upfC-2ooxG:
undetectable		 1upfC-2ooxG:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		4 / 4 MET G 200
ALA G 198
TYR G 232
ILE G 221
 None
 0.96A 1upfD-2ooxG:
undetectable		 1upfD-2ooxG:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU G 304
ILE G 279
MET G 187
LEU G 133
MET G 129
 None
 1.47A 2n27A-2ooxG:
undetectable		 2n27A-2ooxG:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		4 / 5 PRO G  29
SER G  31
LEU G 161
SER G 159
 None
 1.23A 3ijxH-2ooxG:
undetectable		 3ijxH-2ooxG:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		4 / 5 PRO G  29
SER G  31
LEU G 161
SER G 159
 None
 1.33A 3iluH-2ooxG:
undetectable		 3iluH-2ooxG:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		6 / 12 ILE G 303
ASP G 308
THR G 191
ILE G 216
SER G 217
PRO G 220
 AMP  G 401 (-4.0A)
AMP  G 401 (-2.6A)
AMP  G 401 (-3.7A)
AMP  G 401 (-3.7A)
AMP  G 401 (-2.3A)
AMP  G 401 (-4.7A)
 0.77A 3kpbA-2ooxG:
9.3		 3kpbA-2ooxG:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		6 / 12 ILE G 303
ASP G 308
THR G 191
ILE G 216
SER G 217
PRO G 220
 AMP  G 401 (-4.0A)
AMP  G 401 (-2.6A)
AMP  G 401 (-3.7A)
AMP  G 401 (-3.7A)
AMP  G 401 (-2.3A)
AMP  G 401 (-4.7A)
 0.76A 3kpbC-2ooxG:
11.3		 3kpbC-2ooxG:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		5 / 10 ILE G 303
ASP G 308
THR G 191
ILE G 216
SER G 217
 AMP  G 401 (-4.0A)
AMP  G 401 (-2.6A)
AMP  G 401 (-3.7A)
AMP  G 401 (-3.7A)
AMP  G 401 (-2.3A)
 0.59A 3kpbD-2ooxG:
11.2		 3kpbD-2ooxG:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		7 / 11 ILE G 303
ASP G 308
THR G 191
ASN G 215
ILE G 216
SER G 217
PRO G 220
 AMP  G 401 (-4.0A)
AMP  G 401 (-2.6A)
AMP  G 401 (-3.7A)
None
AMP  G 401 (-3.7A)
AMP  G 401 (-2.3A)
AMP  G 401 (-4.7A)
 0.87A 3kpcA-2ooxG:
12.1		 3kpcA-2ooxG:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		7 / 12 ILE G 303
ASP G 308
THR G 191
ASN G 215
ILE G 216
SER G 217
PRO G 220
 AMP  G 401 (-4.0A)
AMP  G 401 (-2.6A)
AMP  G 401 (-3.7A)
None
AMP  G 401 (-3.7A)
AMP  G 401 (-2.3A)
AMP  G 401 (-4.7A)
 0.90A 3kpdB-2ooxG:
11.7		 3kpdB-2ooxG:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		8 / 12 ILE G 303
ASP G 308
THR G 191
ASN G 215
ILE G 216
SER G 217
VAL G 219
PRO G 220
 AMP  G 401 (-4.0A)
AMP  G 401 (-2.6A)
AMP  G 401 (-3.7A)
None
AMP  G 401 (-3.7A)
AMP  G 401 (-2.3A)
AMP  G 401 ( 4.4A)
AMP  G 401 (-4.7A)
 0.87A 3kpdC-2ooxG:
11.7		 3kpdC-2ooxG:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL G  56
VAL G 160
ILE G  35
ARG G 287
 None
 1.26A 3ms9B-2ooxG:
undetectable		 3ms9B-2ooxG:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		5 / 10 ARG G 110
ILE G 115
ILE G  97
TYR G 246
ILE G  94
 None
 1.32A 3ohtA-2ooxG:
undetectable
3ohtB-2ooxG:
undetectable		 3ohtA-2ooxG:
19.90
3ohtB-2ooxG:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		5 / 9 ALA G 307
ILE G 189
GLY G 190
ILE G 303
ILE G 283
 AMP  G 401 ( 4.8A)
None
AMP  G 401 ( 4.5A)
AMP  G 401 (-4.0A)
None
 1.17A 4nptA-2ooxG:
undetectable		 4nptA-2ooxG:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		5 / 12 CYH G 132
LEU G 128
LEU G 167
THR G 177
ILE G 314
 None
 1.10A 4o2bB-2ooxG:
undetectable		 4o2bB-2ooxG:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		3 / 3 ASP G 274
GLY G 278
ASP G 277
 None
 0.54A 4xdtA-2ooxG:
undetectable		 4xdtA-2ooxG:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		4 / 4 GLY G 302
LEU G 276
PHE G 280
ILE G 309
 None
 0.98A 4xv2A-2ooxG:
undetectable		 4xv2A-2ooxG:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE G 279
LEU G 291
ILE G 309
LEU G 167
 None
 0.73A 4zvcA-2ooxG:
undetectable
4zvcB-2ooxG:
undetectable		 4zvcA-2ooxG:
17.24
4zvcB-2ooxG:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE G 309
LEU G 167
ILE G 279
LEU G 291
 None
 0.73A 4zvcA-2ooxG:
undetectable
4zvcB-2ooxG:
undetectable		 4zvcA-2ooxG:
17.24
4zvcB-2ooxG:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		3 / 3 THR G 177
HIS G 289
LEU G 306
 None
 0.75A 5axdA-2ooxG:
undetectable		 5axdA-2ooxG:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		3 / 3 THR G 177
HIS G 289
LEU G 306
 None
 0.78A 5axdC-2ooxG:
undetectable		 5axdC-2ooxG:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		4 / 6 PHE G 292
ARG G 290
PHE G 264
VAL G 235
 None
AMP  G 401 (-4.4A)
None
None
 1.20A 5h4dA-2ooxG:
undetectable		 5h4dA-2ooxG:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		5 / 12 CYH G 132
LEU G 128
LEU G 167
THR G 177
ILE G 314
 None
 1.08A 5mioB-2ooxG:
undetectable		 5mioB-2ooxG:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU G 240
SER G 252
THR G 202
ALA G 198
ASN G 230
 None
 1.47A 6drxA-2ooxG:
undetectable		 6drxA-2ooxG:
22.67