SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2op4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR H 116
PRO H 118
THR H 117
PRO H 149
 None
 1.34A 1dsdC-2op4H:
undetectable		 1dsdC-2op4H:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR H 117
PRO H 149
THR H 116
PRO H 118
 None
 1.25A 1dsdC-2op4H:
undetectable		 1dsdC-2op4H:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR H 116
PRO H 118
THR H 117
PRO H 149
 None
 1.34A 1dsdC-2op4H:
undetectable		 1dsdC-2op4H:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR H 117
PRO H 149
THR H 116
PRO H 118
 None
 1.25A 1dsdC-2op4H:
undetectable		 1dsdC-2op4H:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR H  83
LEU H  82
LEU H  20
GLN H   6
 None
 1.17A 1fbmA-2op4H:
undetectable		 1fbmA-2op4H:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN
(Mus
musculus) 		5 / 10 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.47A 4ldoA-2op4H:
undetectable		 4ldoA-2op4H:
18.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN
(Mus
musculus) 		4 / 5 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.26A 4m7kH-2op4H:
22.9		 4m7kH-2op4H:
70.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN
(Mus
musculus) 		5 / 12 TRP H  33
HIS H  35
TRP H  47
THR H  50
PHE H 100
 None
EDO  H 229 (-4.6A)
None
None
EDO  H 229 (-3.4A)
 0.46A 4uinH-2op4H:
26.5
4uinL-2op4H:
18.0		 4uinH-2op4H:
77.93
4uinL-2op4H:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.46A 6h7mB-2op4H:
undetectable		 6h7mB-2op4H:
19.40