SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2op6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DGM_A_ADNA375_1
(ADENOSINE KINASE)		 2op6 HEAT SHOCK 70 KDA
PROTEIN D
(Caenorhabditis
elegans) 		5 / 9 ASN A 530
ILE A 510
ASP A 506
GLY A 509
ASP A 420
 None
 1.14A 1dgmA-2op6A:
undetectable		 1dgmA-2op6A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2op6 HEAT SHOCK 70 KDA
PROTEIN D
(Caenorhabditis
elegans) 		5 / 12 GLY A 495
ALA A 492
ALA A 462
PHE A 453
ASP A 517
 None
 1.03A 4kicA-2op6A:
undetectable		 4kicA-2op6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2op6 HEAT SHOCK 70 KDA
PROTEIN D
(Caenorhabditis
elegans) 		5 / 12 GLY A 495
ALA A 492
ALA A 462
PHE A 453
ASP A 517
 None
 1.05A 4kicB-2op6A:
undetectable		 4kicB-2op6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2op6 HEAT SHOCK 70 KDA
PROTEIN D
(Caenorhabditis
elegans) 		4 / 5 LEU A 526
PHE A 503
ILE A 465
ILE A 428
 None
 0.89A 5dzk4-2op6A:
undetectable
5dzkg-2op6A:
undetectable
5dzkm-2op6A:
undetectable
5dzkn-2op6A:
undetectable		 5dzk4-2op6A:
0.66
5dzkg-2op6A:
20.81
5dzkm-2op6A:
20.73
5dzkn-2op6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2op6 HEAT SHOCK 70 KDA
PROTEIN D
(Caenorhabditis
elegans) 		4 / 8 ASN A 483
PHE A 484
ILE A 467
GLY A 427
 None
 0.99A 5nzxA-2op6A:
undetectable		 5nzxA-2op6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2op6 HEAT SHOCK 70 KDA
PROTEIN D
(Caenorhabditis
elegans) 		4 / 7 ASN A 483
PHE A 484
ILE A 467
GLY A 427
 None
 1.00A 5nzyA-2op6A:
undetectable		 5nzyA-2op6A:
19.80