SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2opc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2opc AVRL567-A
(Melampsora
lini) 		3 / 3 TYR A 141
LEU A  68
ARG A  43
 None
 0.69A 3sufB-2opcA:
undetectable		 3sufB-2opcA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 2opc AVRL567-A
(Melampsora
lini) 		3 / 3 HIS A  88
HIS A 129
ILE A  86
 None
 0.86A 3u52A-2opcA:
undetectable
3u52C-2opcA:
undetectable		 3u52A-2opcA:
12.23
3u52C-2opcA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2opc AVRL567-A
(Melampsora
lini) 		5 / 12 ALA A 114
GLN A 115
VAL A  49
ILE A  50
LEU A 146
 None
 1.25A 3uvvB-2opcA:
undetectable		 3uvvB-2opcA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2opc AVRL567-A
(Melampsora
lini) 		4 / 6 TYR A 141
PRO A 139
LEU A 130
GLU A 132
 None
 1.39A 4z4cA-2opcA:
undetectable		 4z4cA-2opcA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 2opc AVRL567-A
(Melampsora
lini) 		3 / 3 VAL A  49
LYS A  70
MET A 107
 None
 0.75A 5nknA-2opcA:
undetectable		 5nknA-2opcA:
20.30