SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2opi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A  70
GLY A 135
PRO A 134
 None
 1.01A 2hreB-2opiA:
undetectable		 2hreB-2opiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 HIS A 158
GLY A 159
LEU A  92
SER A  27
VAL A  47
 None
 1.18A 4f84A-2opiA:
undetectable		 4f84A-2opiA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A  92
LEU A  30
SER A  41
SER A  45
 None
 1.00A 4ikjA-2opiA:
undetectable
4ikjB-2opiA:
undetectable		 4ikjA-2opiA:
19.25
4ikjB-2opiA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A  18
ALA A  20
PHE A  94
ALA A 174
VAL A 162
 None
 1.30A 4ryaA-2opiA:
undetectable		 4ryaA-2opiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A   2
HIS A   6
LEU A  39
GLY A  35
 None
 0.98A 4z69A-2opiA:
undetectable		 4z69A-2opiA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLU A 198
PRO A 196
ILE A 199
LEU A 194
 None
 1.08A 5m45A-2opiA:
undetectable		 5m45A-2opiA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLU A 198
PRO A 196
ILE A 199
LEU A 194
 None
 1.13A 5m45D-2opiA:
undetectable		 5m45D-2opiA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLU A 198
PRO A 196
ILE A 199
LEU A 194
 None
 1.07A 5m45G-2opiA:
undetectable		 5m45G-2opiA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 GLU A 198
PRO A 196
ILE A 199
LEU A 194
 None
 1.12A 5m45J-2opiA:
undetectable		 5m45J-2opiA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A  72
SER A  41
PHE A  77
 SO4  A 301 (-2.6A)
None
None
 0.83A 5mugA-2opiA:
undetectable		 5mugA-2opiA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A 100
LEU A  92
GLN A 169
GLU A 172
 None
 1.08A 5tudA-2opiA:
undetectable		 5tudA-2opiA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 2opi L-FUCULOSE-1-PHOSPHA
TE ALDOLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 VAL A 153
HIS A 158
TYR A 132
CYH A 104
 None
 1.30A 6gneB-2opiA:
undetectable		 6gneB-2opiA:
19.83