SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2opj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		3 / 3 GLU A  23
GLU A  35
LEU A 303
 None
 0.60A 1v8bA-2opjA:
3.2		 1v8bA-2opjA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		5 / 12 LEU A  12
LEU A 261
LEU A 258
ILE A  19
VAL A 240
 None
 1.05A 2pnjA-2opjA:
3.1		 2pnjA-2opjA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		4 / 4 LEU A 271
PRO A 269
LEU A 258
ARG A  13
 None
 1.15A 2qd2A-2opjA:
undetectable		 2qd2A-2opjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		6 / 12 GLY A 239
GLY A 235
LEU A 242
ALA A 243
LEU A 255
LEU A 277
 None
 1.42A 2yqzA-2opjA:
undetectable		 2yqzA-2opjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		6 / 12 GLY A 239
GLY A 235
LEU A 242
ALA A 243
LEU A 255
LEU A 277
 None
 1.43A 2yqzB-2opjA:
undetectable		 2yqzB-2opjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		5 / 12 ALA A 217
LEU A 242
LEU A 249
ARG A 128
VAL A 201
 None
 1.16A 3ix9A-2opjA:
undetectable		 3ix9A-2opjA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		5 / 11 ALA A 140
THR A 139
VAL A 168
ALA A 160
GLY A 133
 None
 0.96A 3mg0K-2opjA:
undetectable
3mg0L-2opjA:
undetectable		 3mg0K-2opjA:
20.12
3mg0L-2opjA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		5 / 12 GLY A 239
LEU A 246
GLU A  56
VAL A 204
LEU A 207
 None
 1.13A 4fr0A-2opjA:
undetectable		 4fr0A-2opjA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		4 / 8 LEU A  12
LEU A 261
LEU A 258
ILE A  19
 None
 0.88A 4klaA-2opjA:
undetectable		 4klaA-2opjA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		5 / 10 LEU A 261
LEU A 258
LEU A 270
ARG A  22
ILE A  10
 None
 1.31A 4mk4A-2opjA:
1.7		 4mk4A-2opjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		4 / 8 ARG A 280
ASP A 268
VAL A 234
ASP A 283
 None
 1.06A 4xqgA-2opjA:
undetectable		 4xqgA-2opjA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		4 / 8 ARG A 280
ASP A 268
VAL A 234
ASP A 283
 None
 1.06A 4xqgB-2opjA:
undetectable		 4xqgB-2opjA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		5 / 12 THR A  14
ALA A  84
ALA A 116
ALA A  78
GLY A  80
 None
 1.24A 5jglA-2opjA:
undetectable		 5jglA-2opjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		5 / 12 THR A  14
ALA A  84
ALA A 116
ALA A  78
GLY A  80
 None
 1.27A 5jglB-2opjA:
undetectable		 5jglB-2opjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		5 / 9 ALA A  96
THR A  95
ALA A  74
GLY A 122
ALA A 120
 None
 0.95A 5l5zK-2opjA:
undetectable
5l5zL-2opjA:
undetectable		 5l5zK-2opjA:
22.16
5l5zL-2opjA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		5 / 9 ALA A  96
THR A  95
ALA A  74
GLY A 122
ALA A 120
 None
 0.95A 5l5zY-2opjA:
undetectable
5l5zZ-2opjA:
undetectable		 5l5zY-2opjA:
22.16
5l5zZ-2opjA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		5 / 10 TRP A  51
ALA A  48
GLY A 208
ILE A  19
LEU A  12
 None
 1.07A 5oy01-2opjA:
undetectable
5oy07-2opjA:
undetectable		 5oy01-2opjA:
12.54
5oy07-2opjA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		3 / 3 GLU A 153
ARG A 128
TYR A 154
 None
 0.58A 5trqB-2opjA:
undetectable		 5trqB-2opjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		5 / 12 GLY A  34
ALA A  31
GLU A 231
PHE A  36
PHE A   8
 None
 1.26A 5x6yA-2opjA:
undetectable		 5x6yA-2opjA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2opj O-SUCCINYLBENZOATE-C
OA SYNTHASE
(Thermobifida
fusca) 		4 / 4 GLY A  34
LEU A  26
VAL A 234
GLU A  35
 None
 1.46A 5yw0A-2opjA:
undetectable		 5yw0A-2opjA:
21.73