SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		7 / 8 HIS A  57
ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
BEN  A 245 (-3.0A)
BEN  A 245 (-4.4A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.64A 1aq7A-2oq5A:
34.9		 1aq7A-2oq5A:
37.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		7 / 9 ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.9A)
BEN  A 245 (-3.3A)
None
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.34A 1bcuH-2oq5A:
35.4		 1bcuH-2oq5A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 (-3.4A)
 0.40A 1dwcH-2oq5A:
34.7		 1dwcH-2oq5A:
37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		7 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.45A 1etrH-2oq5A:
34.6		 1etrH-2oq5A:
35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 8 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.34A 1f5lA-2oq5A:
36.5		 1f5lA-2oq5A:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.25A 1tnlA-2oq5A:
14.3		 1tnlA-2oq5A:
37.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		4 / 8 ASP A 217
LYS A 221
GLY A 186
THR A 161
 None
 1.03A 2aouA-2oq5A:
undetectable		 2aouA-2oq5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		4 / 5 LEU A 155
ILE A  75
SER A  32
GLY A  43
 None
 0.97A 2otfA-2oq5A:
undetectable		 2otfA-2oq5A:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.19A 2otvA-2oq5A:
14.5		 2otvA-2oq5A:
37.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		4 / 5 SER A  54
GLY A 197
HIS A  99
ASP A 217
 None
 1.02A 2oxtB-2oq5A:
undetectable		 2oxtB-2oq5A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		4 / 4 SER A  54
GLY A  43
HIS A  99
ASP A 217
 None
 1.20A 2oxtC-2oq5A:
undetectable		 2oxtC-2oq5A:
23.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		8 / 12 ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.9A)
BEN  A 245 (-3.3A)
None
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
None
 0.29A 2p16A-2oq5A:
35.7		 2p16A-2oq5A:
34.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		4 / 6 LEU A  85
LEU A 108
ILE A  88
ARG A  87
 None
 0.93A 2rlfA-2oq5A:
undetectable
2rlfB-2oq5A:
undetectable		 2rlfA-2oq5A:
10.92
2rlfB-2oq5A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 9 LEU A  46
ALA A 106
LEU A 108
ALA A  66
PHE A  68
 None
 1.20A 2vcvD-2oq5A:
undetectable		 2vcvD-2oq5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 9 LEU A  46
ALA A 106
LEU A 108
ALA A  66
PHE A  68
 None
 1.22A 2vcvE-2oq5A:
undetectable		 2vcvE-2oq5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 9 LEU A  46
ALA A 106
LEU A 108
ALA A  66
PHE A  68
 None
 1.25A 2vcvH-2oq5A:
undetectable		 2vcvH-2oq5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 9 LEU A  46
ALA A 106
LEU A 108
ALA A  66
PHE A  68
 None
 1.25A 2vcvI-2oq5A:
undetectable		 2vcvI-2oq5A:
19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 8 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.30A 2vinA-2oq5A:
37.0		 2vinA-2oq5A:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		8 / 12 ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.9A)
BEN  A 245 (-3.3A)
None
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
None
 0.35A 2w26A-2oq5A:
35.7		 2w26A-2oq5A:
34.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		7 / 11 HIS A  57
ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
BEN  A 245 (-3.0A)
BEN  A 245 (-4.4A)
BEN  A 245 (-3.3A)
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.40A 3gy3A-2oq5A:
14.2		 3gy3A-2oq5A:
37.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		4 / 8 VAL A 231
TRP A  29
GLN A  30
ILE A 244
 None
 0.86A 3hjoA-2oq5A:
undetectable		 3hjoA-2oq5A:
18.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 6 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A 245 (-3.3A)
None
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.20A 3rxfA-2oq5A:
14.9		 3rxfA-2oq5A:
37.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		4 / 5 ASP A 189
SER A 195
VAL A 213
GLY A 226
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 (-3.4A)
 0.29A 3rxhA-2oq5A:
14.5		 3rxhA-2oq5A:
37.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 None
BEN  A 245 (-4.4A)
None
BEN  A 245 (-3.3A)
 0.75A 4fu8A-2oq5A:
36.6		 4fu8A-2oq5A:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		6 / 12 HIS A  57
ASP A 189
ALA A 190
VAL A 213
TRP A 215
GLY A 226
 None
BEN  A 245 (-3.0A)
BEN  A 245 (-3.9A)
None
None
BEN  A 245 (-3.4A)
 0.28A 4hfpD-2oq5A:
34.5		 4hfpD-2oq5A:
36.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 9 ALA A  44
THR A  45
ALA A  31
ILE A  88
ALA A 106
 None
 1.16A 4qvqK-2oq5A:
undetectable
4qvqL-2oq5A:
undetectable		 4qvqK-2oq5A:
22.31
4qvqL-2oq5A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 9 ALA A  44
THR A  45
ALA A  31
ILE A  88
ALA A 106
 None
 1.16A 4qvqY-2oq5A:
undetectable
4qvqZ-2oq5A:
undetectable		 4qvqY-2oq5A:
22.31
4qvqZ-2oq5A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		5 / 12 ILE A  47
GLN A  30
THR A 139
LEU A 209
TRP A 207
 None
 1.45A 4qynB-2oq5A:
undetectable		 4qynB-2oq5A:
18.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		6 / 12 HIS A  57
ALA A 190
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
BEN  A 245 (-3.9A)
None
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
 0.84A 4rn6B-2oq5A:
29.3		 4rn6B-2oq5A:
36.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		4 / 4 LEU A 209
MET A 136
ILE A 103
LEU A 181
 None
 1.41A 5nfpA-2oq5A:
undetectable		 5nfpA-2oq5A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens) 		4 / 7 VAL A 200
VAL A 231
PRO A 124
TYR A 208
 None
 0.95A 5x80C-2oq5A:
undetectable
5x80D-2oq5A:
undetectable		 5x80C-2oq5A:
22.13
5x80D-2oq5A:
22.13