SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oqa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		8 / 9 ILE A  71
PHE A  83
GLY A 108
TYR A 110
ILE A 154
ALA A 158
GLU A 159
ARG A 162
 None
 0.32A 1mrgA-2oqaA:
39.8		 1mrgA-2oqaA:
69.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		5 / 9 TYR A  70
TYR A 110
ILE A 154
ALA A 158
GLU A 159
 None
 0.95A 1mrgA-2oqaA:
39.8		 1mrgA-2oqaA:
69.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		6 / 8 ILE A  71
GLY A 108
TYR A 110
ILE A 154
GLU A 159
ARG A 162
 None
 0.31A 1mrjA-2oqaA:
39.9		 1mrjA-2oqaA:
62.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		4 / 6 TYR A 165
ILE A 185
PRO A 180
GLU A 188
 None
 1.44A 1oniA-2oqaA:
undetectable
1oniC-2oqaA:
undetectable		 1oniA-2oqaA:
21.79
1oniC-2oqaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		5 / 10 LEU A 238
ARG A 162
LEU A  25
ILE A  18
ALA A 158
 None
 1.12A 2bxeB-2oqaA:
undetectable		 2bxeB-2oqaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		5 / 12 ALA A  91
PHE A  83
SER A 107
ILE A 154
LEU A 113
 None
 1.16A 2oipD-2oqaA:
undetectable		 2oipD-2oqaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		5 / 12 ALA A  91
PHE A  83
SER A 107
ILE A 154
LEU A 113
 None
 1.08A 2oipE-2oqaA:
undetectable		 2oipE-2oqaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		4 / 8 TYR A  81
TYR A  74
ALA A 149
ALA A 145
 None
 0.91A 2wx2B-2oqaA:
undetectable		 2wx2B-2oqaA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		4 / 6 ARG A 162
ILE A 153
LEU A 138
TYR A 106
 None
 1.07A 2ya7A-2oqaA:
undetectable		 2ya7A-2oqaA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		4 / 6 ARG A 162
ILE A 153
LEU A 138
TYR A 106
 None
 1.04A 2ya7B-2oqaA:
undetectable		 2ya7B-2oqaA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		4 / 6 ARG A 162
ILE A 153
LEU A 138
TYR A 106
 None
 1.06A 2ya7D-2oqaA:
undetectable		 2ya7D-2oqaA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		4 / 7 ILE A 153
GLY A  73
TYR A 141
LEU A 113
 None
 0.92A 3elzA-2oqaA:
undetectable		 3elzA-2oqaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		4 / 8 TYR A  81
TYR A  74
ALA A 149
ALA A 145
 None
 0.98A 3khmA-2oqaA:
undetectable		 3khmA-2oqaA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		4 / 8 TYR A  81
TYR A  74
ALA A 149
ALA A 145
 None
 0.92A 3l4dA-2oqaA:
undetectable		 3l4dA-2oqaA:
16.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		5 / 10 TYR A  70
ILE A  64
ALA A 158
GLU A 159
ARG A 162
 None
 1.38A 3u6tA-2oqaA:
40.7		 3u6tA-2oqaA:
69.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		10 / 10 TYR A  70
ILE A  71
GLU A  85
SER A 107
ASN A 109
TYR A 110
ILE A 154
ALA A 158
GLU A 159
ARG A 162
 None
 0.58A 3u6tA-2oqaA:
40.7		 3u6tA-2oqaA:
69.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		4 / 7 ILE A 153
LEU A 131
PHE A   4
LYS A  16
 None
 1.03A 4hajA-2oqaA:
undetectable		 4hajA-2oqaA:
13.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		4 / 5 ILE A  71
ASN A 109
TYR A 110
ILE A 154
 None
 0.63A 4jtpA-2oqaA:
40.7		 4jtpA-2oqaA:
69.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		4 / 5 TYR A  70
ILE A  71
TYR A 110
ILE A 154
 None
 0.35A 4jtpA-2oqaA:
40.7		 4jtpA-2oqaA:
69.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		5 / 5 TYR A  70
ASN A 109
TYR A 110
ILE A 154
ARG A 162
 None
 0.73A 4o0oA-2oqaA:
40.5		 4o0oA-2oqaA:
69.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		9 / 9 TYR A  70
ILE A  71
PHE A  83
GLY A 108
TYR A 110
ILE A 154
ALA A 158
GLU A 159
ARG A 162
 None
 0.46A 4yp2B-2oqaA:
40.7		 4yp2B-2oqaA:
71.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		9 / 9 TYR A  70
ILE A  71
PHE A  83
GLY A 108
TYR A 110
ILE A 154
ALA A 158
GLU A 159
ARG A 162
 None
 0.43A 5cf9B-2oqaA:
40.7		 5cf9B-2oqaA:
71.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2oqa LUFFACULIN 1
(Luffa
acutangula) 		5 / 6 TYR A  70
TYR A 110
ILE A 154
GLU A 159
ARG A 162
 None
 0.48A 5z3jA-2oqaA:
34.5		 5z3jA-2oqaA:
32.23