SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oqb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 10 SER A  86
ALA A  67
ALA A  68
THR A  89
ILE A  70
 None
 1.19A 1gtnB-2oqbA:
undetectable
1gtnC-2oqbA:
undetectable		 1gtnB-2oqbA:
21.05
1gtnC-2oqbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 10 SER A  86
ALA A  67
ALA A  68
THR A  89
ILE A  70
 None
 1.20A 1gtnH-2oqbA:
undetectable
1gtnI-2oqbA:
undetectable		 1gtnH-2oqbA:
21.05
1gtnI-2oqbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 12 ILE A 101
VAL A  61
LEU A  59
PHE A 112
PHE A  99
 None
 1.28A 2no0A-2oqbA:
undetectable		 2no0A-2oqbA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 12 VAL A  30
ALA A  63
LEU A 125
ILE A 110
LEU A  72
 None
 1.08A 3hj3D-2oqbA:
undetectable		 3hj3D-2oqbA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 9 LEU A 125
VAL A  85
LEU A  59
ILE A  70
PHE A  33
 None
 1.15A 3tbgD-2oqbA:
undetectable		 3tbgD-2oqbA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 10 SER A  86
ALA A  67
ALA A  68
THR A  89
ILE A  70
 None
 1.19A 5eeuF-2oqbA:
undetectable
5eeuG-2oqbA:
undetectable		 5eeuF-2oqbA:
21.05
5eeuG-2oqbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 10 SER A  86
ALA A  67
ALA A  68
THR A  89
ILE A  70
 None
 1.19A 5eevF-2oqbA:
undetectable
5eevG-2oqbA:
undetectable		 5eevF-2oqbA:
21.05
5eevG-2oqbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 10 SER A  86
ALA A  67
ALA A  68
THR A  89
ILE A  70
 None
 1.19A 5eewF-2oqbA:
undetectable
5eewG-2oqbA:
undetectable		 5eewF-2oqbA:
21.05
5eewG-2oqbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		5 / 10 SER A  86
ALA A  67
ALA A  68
THR A  89
ILE A  70
 None
 1.19A 5eexF-2oqbA:
undetectable
5eexG-2oqbA:
undetectable		 5eexF-2oqbA:
21.05
5eexG-2oqbA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		3 / 3 CYH A 128
LYS A 126
HIS A 131
 None
 1.19A 5js5A-2oqbA:
undetectable		 5js5A-2oqbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2oqb HISTONE-ARGININE
METHYLTRANSFERASE
CARM1
(Rattus
norvegicus) 		4 / 4 ARG A  37
GLN A  97
PHE A 118
LEU A 109
 None
 1.28A 6nmfC-2oqbA:
undetectable		 6nmfC-2oqbA:
21.01