SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		5 / 8 ALA A  53
ILE A  71
GLY A  70
GLY A  56
ILE A  30
 None
 0.96A 1sguA-2oqcA:
undetectable		 1sguA-2oqcA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		4 / 5 TYR A 223
PRO A 220
THR A 276
THR A  18
 None
 1.48A 1ymxB-2oqcA:
undetectable		 1ymxB-2oqcA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		5 / 12 CYH A   1
ARG A  17
MET A  19
ALA A  68
LEU A 142
 None
 0.34A 2bjfA-2oqcA:
43.3		 2bjfA-2oqcA:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z71_A_PNVA903_1
(PENICILLIN ACYLASE)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		5 / 10 TYR A  82
ASN A 175
PRO A 225
ARG A 228
GLU A 270
 None
 0.75A 2z71A-2oqcA:
46.4
2z71C-2oqcA:
46.6		 2z71A-2oqcA:
40.12
2z71C-2oqcA:
40.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z71_C_PNVC904_1
(PENICILLIN ACYLASE)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		5 / 10 TYR A  82
ASN A 175
ARG A 228
THR A 268
GLU A 270
 None
 0.74A 2z71A-2oqcA:
46.4
2z71C-2oqcA:
46.6		 2z71A-2oqcA:
40.12
2z71C-2oqcA:
40.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		4 / 7 THR A 246
VAL A 249
THR A 250
ILE A 299
 None
 0.86A 3deuA-2oqcA:
undetectable		 3deuA-2oqcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		5 / 11 THR A  18
ALA A 252
ILE A 255
THR A 286
GLU A 245
 None
 1.49A 3qelA-2oqcA:
undetectable
3qelB-2oqcA:
undetectable		 3qelA-2oqcA:
22.66
3qelB-2oqcA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		4 / 5 GLU A  28
GLY A  26
TYR A 278
GLN A 277
 None
 1.15A 3w9tB-2oqcA:
undetectable		 3w9tB-2oqcA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD506_1
(HEMOLYTIC LECTIN
CEL-III)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		4 / 5 GLU A  28
GLY A  26
TYR A 278
GLN A 277
 None
 1.16A 3w9tD-2oqcA:
undetectable		 3w9tD-2oqcA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		4 / 5 GLU A  28
GLY A  26
TYR A 278
GLN A 277
 None
 1.20A 3w9tE-2oqcA:
undetectable		 3w9tE-2oqcA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG505_1
(HEMOLYTIC LECTIN
CEL-III)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		4 / 5 GLU A  28
GLY A  26
TYR A 278
GLN A 277
 None
 1.21A 3w9tG-2oqcA:
undetectable		 3w9tG-2oqcA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		4 / 5 ARG A 228
VAL A 172
LEU A   4
SER A   3
 None
 1.38A 4e1gA-2oqcA:
undetectable		 4e1gA-2oqcA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		5 / 11 LEU A   4
ALA A  16
THR A 276
ILE A 261
ASP A  20
 None
 1.24A 4uuuA-2oqcA:
undetectable
4uuuB-2oqcA:
undetectable		 4uuuA-2oqcA:
19.63
4uuuB-2oqcA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		5 / 11 LEU A   4
ALA A  16
THR A 276
ILE A 261
ASP A  20
 None
 1.26A 4uuuB-2oqcA:
undetectable		 4uuuB-2oqcA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		4 / 7 VAL A 316
ILE A  30
LEU A 135
LEU A  61
 None
 0.94A 4xo7A-2oqcA:
undetectable		 4xo7A-2oqcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		4 / 7 LEU A 116
THR A 155
THR A   5
LEU A  15
 None
 0.96A 4z91F-2oqcA:
undetectable
4z91G-2oqcA:
undetectable
4z91H-2oqcA:
undetectable
4z91I-2oqcA:
undetectable
4z91J-2oqcA:
undetectable		 4z91F-2oqcA:
22.74
4z91G-2oqcA:
22.74
4z91H-2oqcA:
22.74
4z91I-2oqcA:
22.74
4z91J-2oqcA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		3 / 3 THR A 150
HIS A  13
ASN A 284
 None
 1.00A 5n4tA-2oqcA:
undetectable		 5n4tA-2oqcA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		5 / 12 ALA A  79
GLY A  70
GLY A  56
ILE A  30
LEU A  61
 None
 1.19A 5ul4A-2oqcA:
undetectable		 5ul4A-2oqcA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		3 / 3 TYR A  52
ARG A  34
THR A  50
 None
 0.97A 5z84J-2oqcA:
undetectable		 5z84J-2oqcA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 2oqc PENICILLIN V ACYLASE
(Bacillus
subtilis) 		5 / 12 ILE A  71
LEU A 146
VAL A 109
LEU A 304
LEU A 309
 None
 1.19A 6b54A-2oqcA:
undetectable		 6b54A-2oqcA:
22.13