SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oqt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2oqt HYPOTHETICAL PROTEIN
SPY0176
(Streptococcus
pyogenes) 		4 / 8 LEU A 100
ALA A  29
VAL A  30
TYR A  57
 None
 0.83A 1epbB-2oqtA:
undetectable		 1epbB-2oqtA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 2oqt HYPOTHETICAL PROTEIN
SPY0176
(Streptococcus
pyogenes) 		5 / 12 TYR A  58
ALA A  29
LEU A  28
THR A  21
ILE A  48
 None
 1.30A 1mx8A-2oqtA:
undetectable		 1mx8A-2oqtA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 2oqt HYPOTHETICAL PROTEIN
SPY0176
(Streptococcus
pyogenes) 		3 / 3 ASN A  78
ALA A   6
ASN A  10
 None
 0.65A 1n4fA-2oqtA:
undetectable		 1n4fA-2oqtA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2oqt HYPOTHETICAL PROTEIN
SPY0176
(Streptococcus
pyogenes) 		5 / 12 PHE A  91
LEU A  85
VAL A  89
VAL A  30
ALA A  29
 None
 1.15A 1q23H-2oqtA:
undetectable
1q23I-2oqtA:
undetectable		 1q23H-2oqtA:
18.50
1q23I-2oqtA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2oqt HYPOTHETICAL PROTEIN
SPY0176
(Streptococcus
pyogenes) 		3 / 3 LEU A 103
HIS A  68
MET A  66
 None
 0.79A 3thrD-2oqtA:
undetectable		 3thrD-2oqtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2oqt HYPOTHETICAL PROTEIN
SPY0176
(Streptococcus
pyogenes) 		5 / 7 TYR A  58
VAL A  59
PHE A  91
VAL A  26
ILE A 119
 None
 1.43A 3zjqA-2oqtA:
undetectable		 3zjqA-2oqtA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2oqt HYPOTHETICAL PROTEIN
SPY0176
(Streptococcus
pyogenes) 		5 / 7 TYR A  58
VAL A  59
PHE A  91
VAL A  26
ILE A 119
 None
 1.42A 3zjqB-2oqtA:
undetectable		 3zjqB-2oqtA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2oqt HYPOTHETICAL PROTEIN
SPY0176
(Streptococcus
pyogenes) 		4 / 6 ALA A   6
GLN A   5
LEU A   3
LEU A 142
 None
 1.17A 4xoyA-2oqtA:
undetectable		 4xoyA-2oqtA:
18.95