SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2or0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 12 GLY A 236
VAL A 364
ALA A  68
PHE A  60
LEU A  44
 None
 1.28A 1nw3A-2or0A:
undetectable		 1nw3A-2or0A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 12 GLY A 236
VAL A 364
ALA A  68
PHE A  60
PHE A 233
 None
 0.89A 1nw3A-2or0A:
undetectable		 1nw3A-2or0A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 9 LEU A  36
LEU A   5
VAL A  64
GLY A  66
ALA A  68
 None
 1.27A 1pxxB-2or0A:
undetectable		 1pxxB-2or0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 10 LEU A  36
LEU A   5
VAL A  64
GLY A  66
ALA A  68
 None
 1.27A 1pxxD-2or0A:
undetectable		 1pxxD-2or0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 11 GLY A  75
LEU A 183
ILE A  42
HIS A 139
ALA A  41
 None
 1.41A 2a58A-2or0A:
undetectable
2a58E-2or0A:
undetectable		 2a58A-2or0A:
15.71
2a58E-2or0A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 11 ILE A  42
HIS A 139
ALA A  41
GLY A  75
LEU A 183
 None
 1.40A 2a58C-2or0A:
undetectable
2a58D-2or0A:
undetectable		 2a58C-2or0A:
15.71
2a58D-2or0A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		4 / 6 PHE A  90
VAL A  83
LEU A  45
ALA A  89
 None
 1.06A 2e1qC-2or0A:
undetectable		 2e1qC-2or0A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		4 / 6 TRP A 100
PRO A  47
LEU A 224
GLY A  82
 None
 1.17A 2hs2B-2or0A:
undetectable		 2hs2B-2or0A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 12 ALA A  91
GLN A  94
GLY A 200
ASP A  92
LEU A 204
 None
 1.34A 2nv4A-2or0A:
undetectable		 2nv4A-2or0A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 12 GLY A  79
GLY A  75
GLY A 243
THR A  78
HIS A  84
 None
 1.01A 2oxtC-2or0A:
undetectable		 2oxtC-2or0A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		4 / 8 VAL A  55
LEU A 291
GLY A 236
ALA A 239
 None
 0.56A 2xfsA-2or0A:
1.8		 2xfsA-2or0A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		4 / 8 VAL A  55
LEU A 291
GLY A 236
ALA A 239
 None
 0.55A 2xh9A-2or0A:
1.9		 2xh9A-2or0A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 12 GLY A 316
ALA A 323
ALA A 295
ILE A 321
PRO A 228
 None
 1.02A 3jayA-2or0A:
1.5		 3jayA-2or0A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		3 / 3 SER A 135
SER A 134
HIS A 139
 None
 0.69A 3mzeA-2or0A:
undetectable		 3mzeA-2or0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		3 / 3 SER A 188
SER A 134
HIS A 139
 None
 0.77A 3mzeA-2or0A:
undetectable		 3mzeA-2or0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		3 / 4 SER A 160
GLY A 385
GLU A 382
 None
 0.69A 3raeA-2or0A:
undetectable
3raeC-2or0A:
undetectable		 3raeA-2or0A:
21.26
3raeC-2or0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 12 LEU A  36
LEU A   5
VAL A  64
GLY A  66
ALA A  68
 None
 0.98A 4rrxA-2or0A:
undetectable		 4rrxA-2or0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 12 LEU A  36
LEU A   5
VAL A  64
GLY A  66
ALA A  68
 None
 0.99A 4rrxB-2or0A:
undetectable		 4rrxB-2or0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		3 / 3 ASN A 205
ALA A 207
ARG A 213
 ACT  A 601 (-3.6A)
ACT  A 601 ( 4.3A)
ACT  A 601 ( 3.3A)
 0.78A 5cvtB-2or0A:
undetectable		 5cvtB-2or0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 12 PRO A  47
GLY A 101
ASN A 104
MET A 108
LEU A  88
 None
 1.00A 5emlA-2or0A:
undetectable		 5emlA-2or0A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		3 / 3 THR A  29
ASP A  30
ALA A  31
 None
 0.08A 5g5gB-2or0A:
undetectable		 5g5gB-2or0A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 12 GLY A  52
VAL A  67
GLY A  82
PHE A 225
ILE A  42
 None
 1.13A 5vooD-2or0A:
undetectable		 5vooD-2or0A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		3 / 3 ARG A  27
ARG A  37
ARG A 168
 None
 1.01A 6bplA-2or0A:
3.9
6bplB-2or0A:
undetectable		 6bplA-2or0A:
10.19
6bplB-2or0A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2or0 HYDROXYLASE
(Rhodococcus
jostii) 		5 / 8 GLY A 236
LEU A 235
THR A  63
VAL A  55
LEU A  45
 None
 1.49A 6czmD-2or0A:
undetectable
6czmF-2or0A:
undetectable		 6czmD-2or0A:
22.74
6czmF-2or0A:
22.74