SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2or8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2or8 HEPATITIS A VIRUS
CELLULAR RECEPTOR 1
HOMOLOG
(Mus
musculus) 		4 / 7 VAL A  81
ARG A  34
VAL A  15
GLU A  82
 None
 1.24A 3dqrA-2or8A:
undetectable
3dqrB-2or8A:
undetectable		 3dqrA-2or8A:
14.64
3dqrB-2or8A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2or8 HEPATITIS A VIRUS
CELLULAR RECEPTOR 1
HOMOLOG
(Mus
musculus) 		4 / 7 VAL A  81
ARG A  34
VAL A  15
GLU A  82
 None
 1.23A 3jx5A-2or8A:
undetectable
3jx5B-2or8A:
undetectable		 3jx5A-2or8A:
14.64
3jx5B-2or8A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_B_AG2B1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2or8 HEPATITIS A VIRUS
CELLULAR RECEPTOR 1
HOMOLOG
(Mus
musculus) 		5 / 9 GLY A   9
TYR A  88
LEU A  46
ASP A  84
SER A  80
 None
 1.47A 3n2oA-2or8A:
0.0
3n2oB-2or8A:
0.0		 3n2oA-2or8A:
10.19
3n2oB-2or8A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2or8 HEPATITIS A VIRUS
CELLULAR RECEPTOR 1
HOMOLOG
(Mus
musculus) 		5 / 10 ASP A  84
SER A  80
GLY A   9
TYR A  88
LEU A  46
 None
 1.44A 3n2oC-2or8A:
undetectable
3n2oD-2or8A:
undetectable		 3n2oC-2or8A:
10.19
3n2oD-2or8A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2or8 HEPATITIS A VIRUS
CELLULAR RECEPTOR 1
HOMOLOG
(Mus
musculus) 		4 / 7 GLU A  82
VAL A  81
ARG A  34
VAL A  15
 None
 1.26A 3nlqA-2or8A:
undetectable
3nlqB-2or8A:
undetectable		 3nlqA-2or8A:
14.64
3nlqB-2or8A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2or8 HEPATITIS A VIRUS
CELLULAR RECEPTOR 1
HOMOLOG
(Mus
musculus) 		4 / 7 GLU A  82
VAL A  81
ARG A  34
VAL A  15
 None
 1.25A 5addA-2or8A:
undetectable
5addB-2or8A:
undetectable		 5addA-2or8A:
14.64
5addB-2or8A:
14.64