SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2orv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		4 / 8 ASP A  58
ASP A  97
GLY A  99
THR A 163
 4TA  A 801 (-3.5A)
4TA  A 801 (-2.7A)
None
4TA  A 801 ( 4.2A)
 0.87A 1m4iA-2orvA:
undetectable		 1m4iA-2orvA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		4 / 8 ALA A  88
ASP A  97
ILE A  96
ILE A 105
 None
4TA  A 801 (-2.7A)
None
None
 0.92A 1p7lD-2orvA:
undetectable		 1p7lD-2orvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		4 / 8 ALA A  88
ASP A  97
ILE A  96
ILE A 105
 None
4TA  A 801 (-2.7A)
None
None
 0.92A 1rg9B-2orvA:
undetectable		 1rg9B-2orvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		4 / 8 ALA A  88
ASP A  97
ILE A  96
ILE A 105
 None
4TA  A 801 (-2.7A)
None
None
 0.91A 1rg9A-2orvA:
undetectable		 1rg9A-2orvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		4 / 8 ALA A  88
ASP A  97
ILE A  96
ILE A 105
 None
4TA  A 801 (-2.7A)
None
None
 0.92A 1rg9D-2orvA:
undetectable		 1rg9D-2orvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		5 / 12 LEU A 137
ALA A 123
ILE A 105
ILE A  96
ILE A 136
 None
 0.89A 2hs1B-2orvA:
undetectable		 2hs1B-2orvA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		4 / 8 ALA A  88
ASP A  97
ILE A  96
ILE A 105
 None
4TA  A 801 (-2.7A)
None
None
 0.96A 4ndnD-2orvA:
undetectable		 4ndnD-2orvA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		5 / 12 LEU A 137
ALA A 123
ILE A 105
ILE A  96
ILE A 136
 None
 0.92A 4q1yB-2orvA:
undetectable		 4q1yB-2orvA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		4 / 8 ARG A 130
GLY A  26
PRO A  27
ASP A 125
 None
 1.07A 5kf8A-2orvA:
undetectable		 5kf8A-2orvA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		4 / 8 ARG A 130
GLY A  26
PRO A  27
ASP A 125
 None
 1.03A 5kgpA-2orvA:
undetectable		 5kgpA-2orvA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		4 / 8 ARG A 130
GLY A  26
PRO A  27
ASP A 125
 None
 1.03A 5kgpB-2orvA:
undetectable		 5kgpB-2orvA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 2orv THYMIDINE KINASE
(Homo
sapiens) 		4 / 8 LEU A  81
ALA A 123
VAL A  84
TYR A  55
 None
 0.91A 5nu7A-2orvA:
undetectable		 5nu7A-2orvA:
24.19