SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ory'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 11 LEU A 293
HIS A 312
ALA A 207
PHE A 206
GLY A 177
 None
 1.33A 1cmaA-2oryA:
undetectable
1cmaB-2oryA:
undetectable		 1cmaA-2oryA:
17.32
1cmaB-2oryA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 10 ALA A 207
PHE A 206
GLY A 177
LEU A 293
HIS A 312
 None
 1.26A 1cmcA-2oryA:
undetectable
1cmcB-2oryA:
undetectable		 1cmcA-2oryA:
17.32
1cmcB-2oryA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 10 LEU A 293
HIS A 312
ALA A 207
PHE A 206
GLY A 177
 None
 1.33A 1cmcA-2oryA:
undetectable
1cmcB-2oryA:
undetectable		 1cmcA-2oryA:
17.32
1cmcB-2oryA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 11 LEU A 293
HIS A 312
ALA A 207
PHE A 206
GLY A 177
 None
 1.31A 1mjqA-2oryA:
undetectable
1mjqB-2oryA:
undetectable		 1mjqA-2oryA:
17.69
1mjqB-2oryA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 10 LEU A 293
HIS A 312
ALA A 207
PHE A 206
GLY A 177
 None
 1.31A 1mjqC-2oryA:
undetectable
1mjqD-2oryA:
undetectable		 1mjqC-2oryA:
17.69
1mjqD-2oryA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 11 LEU A 293
HIS A 312
ALA A 207
PHE A 206
GLY A 177
 None
 1.31A 1mjqI-2oryA:
undetectable
1mjqJ-2oryA:
undetectable		 1mjqI-2oryA:
17.69
1mjqJ-2oryA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 11 PHE A 105
ALA A 269
ALA A 273
VAL A 107
LEU A 101
 None
 1.13A 1rlbF-2oryA:
undetectable		 1rlbF-2oryA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 12 GLY A 176
SER A 174
GLY A 208
ARG A  90
ILE A  87
 None
 1.17A 2b25B-2oryA:
undetectable		 2b25B-2oryA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2ory LIPASE
(Photobacterium
sp.
M37) 		4 / 6 LEU A 133
ALA A 211
ASP A 189
TYR A 115
 None
 1.16A 2dpzA-2oryA:
undetectable		 2dpzA-2oryA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ory LIPASE
(Photobacterium
sp.
M37) 		3 / 3 LEU A 305
TYR A 304
GLN A 307
 None
 0.75A 2wekA-2oryA:
undetectable		 2wekA-2oryA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 12 THR A 210
GLY A 212
ASN A 213
GLY A 177
ASN A 243
 None
 1.17A 3eeyB-2oryA:
undetectable		 3eeyB-2oryA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 12 THR A 210
GLY A 212
ASN A 213
GLY A 177
ASN A 243
 None
 1.15A 3eeyC-2oryA:
undetectable		 3eeyC-2oryA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 12 THR A 210
GLY A 212
ASN A 213
GLY A 177
ASN A 243
 None
 1.16A 3eeyH-2oryA:
undetectable		 3eeyH-2oryA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 12 THR A 210
GLY A 212
ASN A 213
GLY A 177
ASN A 243
 None
 1.16A 3eeyI-2oryA:
undetectable		 3eeyI-2oryA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 12 TYR A  74
ILE A 204
GLY A 172
ALA A 207
ALA A  11
 None
 1.00A 3jb2A-2oryA:
undetectable		 3jb2A-2oryA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 8 TYR A 283
GLY A 208
ALA A 178
THR A 182
ILE A 125
 None
 1.15A 3jusB-2oryA:
0.6		 3jusB-2oryA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 9 TYR A 283
GLY A 208
ALA A 178
THR A 182
ILE A 125
 None
 1.15A 3jusB-2oryA:
0.7		 3jusB-2oryA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 12 TYR A 283
GLY A 208
ALA A 178
THR A 182
ILE A 125
 None
 1.02A 3ld6B-2oryA:
undetectable		 3ld6B-2oryA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 9 LEU A  41
LYS A 167
PHE A  12
MET A   9
LYS A   5
 None
 1.29A 3sj4X-2oryA:
undetectable		 3sj4X-2oryA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2ory LIPASE
(Photobacterium
sp.
M37) 		4 / 8 GLY A 338
ALA A 337
ASP A 334
PRO A  94
 None
 0.76A 4eyrB-2oryA:
undetectable		 4eyrB-2oryA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 12 LEU A 195
LEU A 187
LEU A 183
ILE A 160
THR A 171
 None
 1.18A 4f4dA-2oryA:
undetectable		 4f4dA-2oryA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 2ory LIPASE
(Photobacterium
sp.
M37) 		4 / 6 ILE A 271
TYR A 254
TYR A 304
PHE A 102
 None
 1.22A 4g10A-2oryA:
undetectable		 4g10A-2oryA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 8 LEU A 187
LEU A 183
LYS A 159
ILE A 160
VAL A  75
 None
 1.48A 4klaA-2oryA:
undetectable		 4klaA-2oryA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 8 LEU A 195
LEU A 187
LEU A 183
ILE A 160
VAL A  75
 None
 1.46A 4klaA-2oryA:
undetectable		 4klaA-2oryA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 12 PHE A 216
ALA A 217
VAL A 170
LEU A 224
LEU A 133
 None
 1.21A 4qynA-2oryA:
undetectable		 4qynA-2oryA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2ory LIPASE
(Photobacterium
sp.
M37) 		5 / 12 SER A 181
THR A 182
CYH A 228
ALA A 217
THR A 210
 None
 1.41A 5d0xH-2oryA:
undetectable
5d0xI-2oryA:
undetectable		 5d0xH-2oryA:
20.87
5d0xI-2oryA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_ACTA305_0
(CARBONIC ANHYDRASE 4)		 2ory LIPASE
(Photobacterium
sp.
M37) 		4 / 4 GLN A 307
VAL A 261
GLU A 303
ILE A 302
 None
 1.20A 5jncA-2oryA:
0.0		 5jncA-2oryA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ory LIPASE
(Photobacterium
sp.
M37) 		3 / 3 LEU A 339
ILE A 336
TYR A  14
 None
 0.54A 5uunB-2oryA:
undetectable		 5uunB-2oryA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 2ory LIPASE
(Photobacterium
sp.
M37) 		4 / 5 GLU A  49
PRO A  46
GLN A   7
MET A 322
 None
 1.32A 6fgdA-2oryA:
undetectable		 6fgdA-2oryA:
20.99