SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2os1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		3 / 3 HIS A 157
ILE A  73
LEU A  41
 NI  A 300 ( 3.5A)
None
None
 0.75A 2kceA-2os1A:
undetectable		 2kceA-2os1A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		5 / 10 LEU A 188
ILE A 153
ARG A 127
VAL A  75
GLY A  60
 BB2  A 400 (-4.4A)
BB2  A 400 (-4.4A)
None
None
BB2  A 400 (-4.4A)
 1.18A 2qd4B-2os1A:
undetectable		 2qd4B-2os1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		4 / 5 LEU A  41
HIS A 157
GLU A 158
HIS A 161
 None
NI  A 300 ( 3.5A)
BB2  A 400 (-2.6A)
NI  A 300 ( 3.5A)
 0.84A 4a7bB-2os1A:
undetectable		 4a7bB-2os1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		5 / 12 GLY A  60
ALA A  74
ARG A 127
GLU A 112
HIS A 161
 BB2  A 400 (-4.4A)
None
None
BB2  A 400 ( 3.9A)
NI  A 300 ( 3.5A)
 1.09A 4azsA-2os1A:
undetectable		 4azsA-2os1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		4 / 7 ARG A  71
ALA A  62
ILE A  68
LEU A  33
 None
 0.95A 5te8C-2os1A:
undetectable		 5te8C-2os1A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		3 / 3 ILE A 131
VAL A 133
PRO A  96
 None
 0.67A 5uunA-2os1A:
undetectable		 5uunA-2os1A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		3 / 3 HIS A 161
HIS A 157
ARG A 127
 NI  A 300 ( 3.5A)
NI  A 300 ( 3.5A)
None
 1.11A 6b58A-2os1A:
undetectable		 6b58A-2os1A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		4 / 4 ASP A  36
ILE A  68
PRO A  64
LEU A  66
 None
 1.18A 6mkeB-2os1A:
undetectable		 6mkeB-2os1A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2os1 PEPTIDE DEFORMYLASE
(Enterococcus
faecalis) 		4 / 4 ASP A  36
ILE A  68
PRO A  64
LEU A  66
 None
 1.20A 6mkeA-2os1A:
undetectable		 6mkeA-2os1A:
18.29