SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2os3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  46
LEU A  73
ILE A  78
ILE A   8
LEU A   7
 None
 0.98A 1kyvA-2os3A:
undetectable
1kyvE-2os3A:
undetectable		 1kyvA-2os3A:
21.74
1kyvE-2os3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		5 / 12 ILE A   8
LEU A   7
GLY A  46
LEU A  73
ILE A  78
 None
 1.00A 1kyvB-2os3A:
undetectable
1kyvC-2os3A:
undetectable		 1kyvB-2os3A:
21.74
1kyvC-2os3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		5 / 12 ILE A   8
LEU A   7
GLY A  46
LEU A  73
ILE A  78
 None
 1.01A 1kyvC-2os3A:
undetectable
1kyvD-2os3A:
undetectable		 1kyvC-2os3A:
21.74
1kyvD-2os3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		5 / 12 ILE A   8
LEU A   7
GLY A  46
LEU A  73
ILE A  78
 None
 1.01A 1kyvD-2os3A:
undetectable
1kyvE-2os3A:
undetectable		 1kyvD-2os3A:
21.74
1kyvE-2os3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		5 / 10 ALA A  69
VAL A  71
HIS A 174
GLU A 175
HIS A 178
 None
BB2  A 400 ( 3.8A)
CO  A 300 ( 3.6A)
BB2  A 400 (-2.8A)
CO  A 300 ( 3.4A)
 0.56A 1r55A-2os3A:
undetectable		 1r55A-2os3A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		3 / 3 LYS A   2
ILE A  20
THR A  15
 None
 0.83A 1rx3A-2os3A:
undetectable		 1rx3A-2os3A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		4 / 8 LEU A 205
ARG A 144
VAL A  87
GLY A  72
 None
None
None
BB2  A 400 (-4.6A)
 0.87A 2po5B-2os3A:
undetectable		 2po5B-2os3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		5 / 10 LEU A 205
ILE A 170
ARG A 144
VAL A  87
GLY A  72
 None
BB2  A 400 ( 4.9A)
None
None
BB2  A 400 (-4.6A)
 1.21A 2qd4B-2os3A:
0.0		 2qd4B-2os3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		4 / 8 LEU A 205
ARG A 144
VAL A  87
GLY A  72
 None
None
None
BB2  A 400 (-4.6A)
 0.74A 2qd5B-2os3A:
undetectable		 2qd5B-2os3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		3 / 3 HIS A 174
GLU A 175
HIS A 178
 CO  A 300 ( 3.6A)
BB2  A 400 (-2.8A)
CO  A 300 ( 3.4A)
 0.22A 3kecB-2os3A:
undetectable		 3kecB-2os3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		4 / 7 TYR A 111
VAL A  87
ILE A 176
MET A  50
 None
 1.25A 3ms9B-2os3A:
undetectable		 3ms9B-2os3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  27
ILE A  78
HIS A 174
VAL A 138
GLU A 175
 None
None
CO  A 300 ( 3.6A)
None
BB2  A 400 (-2.8A)
 1.13A 3w1wB-2os3A:
undetectable		 3w1wB-2os3A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		4 / 5 LEU A  53
HIS A 174
GLU A 175
HIS A 178
 None
CO  A 300 ( 3.6A)
BB2  A 400 (-2.8A)
CO  A 300 ( 3.4A)
 0.84A 4a7bB-2os3A:
undetectable		 4a7bB-2os3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		3 / 3 HIS A 178
HIS A 174
ARG A 144
 CO  A 300 ( 3.4A)
CO  A 300 ( 3.6A)
None
 1.10A 6b58A-2os3A:
undetectable		 6b58A-2os3A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2os3 PEPTIDE DEFORMYLASE
(Streptococcus
pyogenes) 		3 / 3 VAL A  80
ALA A  75
GLN A   4
 None
 0.70A 6gb9A-2os3A:
undetectable		 6gb9A-2os3A:
17.07