SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2osa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.10A 1jffB-2osaA:
undetectable		 1jffB-2osaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 LEU A 343
VAL A 274
LEU A 273
LEU A 270
LEU A 397
 None
 1.26A 1mx1C-2osaA:
undetectable		 1mx1C-2osaA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 GLU A 291
ASP A 335
ASN A 337
GLY A 296
SER A 294
 None
 1.21A 1q8jA-2osaA:
undetectable		 1q8jA-2osaA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 GLU A 291
ASP A 335
ASN A 337
GLY A 296
SER A 294
 None
 1.20A 1q8jB-2osaA:
undetectable		 1q8jB-2osaA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2osa N-CHIMAERIN
(Homo
sapiens) 		3 / 3 GLU A 334
GLU A 291
LEU A 302
 None
 0.73A 1v8bA-2osaA:
undetectable		 1v8bA-2osaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 10 ALA A 318
TYR A 266
ILE A 338
GLU A 313
ILE A 312
 None
 1.35A 2dm6A-2osaA:
undetectable
2dm6B-2osaA:
undetectable		 2dm6A-2osaA:
20.90
2dm6B-2osaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 GLU A 291
ASP A 335
ASN A 337
GLY A 296
SER A 294
 None
 1.15A 2e7fA-2osaA:
undetectable		 2e7fA-2osaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 11 LEU A 379
LEU A 450
ILE A 364
ASN A 439
LEU A 394
 None
 1.36A 2ft9A-2osaA:
undetectable		 2ft9A-2osaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 LEU A 426
LEU A 397
MET A 398
LEU A 302
VAL A 404
 None
 1.14A 2hrcB-2osaA:
undetectable		 2hrcB-2osaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.10A 2hxfB-2osaA:
undetectable		 2hxfB-2osaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.10A 2hxhB-2osaA:
undetectable		 2hxhB-2osaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2osa N-CHIMAERIN
(Homo
sapiens) 		6 / 12 GLU A 291
ASP A 335
ASN A 337
GLY A 296
SER A 294
ILE A 336
 None
 1.48A 2ogyA-2osaA:
undetectable		 2ogyA-2osaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 GLU A 291
ASP A 335
ASN A 337
GLY A 296
SER A 294
 None
 1.20A 2ogyB-2osaA:
undetectable		 2ogyB-2osaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.10A 2p4nB-2osaA:
undetectable		 2p4nB-2osaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 TYR A 266
ALA A 342
VAL A 315
MET A 287
HIS A 277
 None
 1.00A 2qo4A-2osaA:
undetectable		 2qo4A-2osaA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.10A 2wbeB-2osaA:
undetectable		 2wbeB-2osaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.10A 3dcoB-2osaA:
undetectable		 3dcoB-2osaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.09A 3edlB-2osaA:
undetectable		 3edlB-2osaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.08A 3iz0B-2osaA:
undetectable		 3iz0B-2osaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 GLU A 291
ASP A 335
ASN A 337
GLY A 296
SER A 294
 None
 1.18A 3k13B-2osaA:
undetectable		 3k13B-2osaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2osa N-CHIMAERIN
(Homo
sapiens) 		3 / 3 GLY A 301
ILE A 420
VAL A 421
 None
 0.40A 3nv6A-2osaA:
undetectable		 3nv6A-2osaA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 GLU A 291
ASP A 335
ASN A 337
GLY A 296
SER A 294
 None
 1.25A 4djfB-2osaA:
undetectable		 4djfB-2osaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 11 ILE A 312
ALA A 342
GLU A 291
GLY A 323
GLU A 313
 None
 1.43A 4jdsD-2osaA:
undetectable		 4jdsD-2osaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 11 LEU A 450
VAL A 448
PHE A 459
LEU A 383
SER A 366
 None
 1.34A 4zbqA-2osaA:
undetectable		 4zbqA-2osaA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.05A 5hnwB-2osaA:
undetectable		 5hnwB-2osaA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
ARG A 281
 None
 1.11A 5hnyB-2osaA:
undetectable		 5hnyB-2osaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
ARG A 281
LEU A 343
 None
 1.14A 5ogcB-2osaA:
undetectable		 5ogcB-2osaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 THR A 356
ILE A 352
LEU A 401
PHE A 347
LEU A 343
 None
 1.05A 6a93A-2osaA:
undetectable		 6a93A-2osaA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 2osa N-CHIMAERIN
(Homo
sapiens) 		5 / 12 VAL A 404
LEU A 394
PHE A 422
LEU A 426
LEU A 343
 None
 1.21A 6ew0G-2osaA:
undetectable		 6ew0G-2osaA:
16.38