SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2osy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		5 / 12 GLY A 157
GLY A 154
SER A  67
ALA A  65
VAL A 187
 None
 1.27A 1i9gA-2osyA:
undetectable		 1i9gA-2osyA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_C_SPMC921_1
(FMS1 PROTEIN)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		5 / 11 ASN A 232
LEU A 286
LEU A 249
TYR A 301
CYH A 302
 GLC  A 600 (-2.7A)
None
None
None
None
 1.32A 1xpqC-2osyA:
0.0		 1xpqC-2osyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		5 / 12 TYR A 369
GLY A  88
THR A  89
GLU A  83
ILE A 365
 None
 1.36A 2akeA-2osyA:
2.1		 2akeA-2osyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		5 / 12 TYR A 369
GLY A  88
THR A  89
GLU A  83
ILE A 365
 None
 1.35A 2azxB-2osyA:
undetectable		 2azxB-2osyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		5 / 11 TYR A 369
GLY A  88
THR A  89
GLU A  83
ILE A 365
 None
 1.38A 2dr2A-2osyA:
2.2		 2dr2A-2osyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		5 / 8 TYR A 369
GLY A 350
GLY A 378
ALA A 372
ALA A 377
 None
 1.41A 2ej3C-2osyA:
undetectable		 2ej3C-2osyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		4 / 7 PHE A 191
THR A 165
ILE A 276
GLY A 157
 None
 0.75A 2v0mB-2osyA:
undetectable		 2v0mB-2osyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		3 / 3 PRO A  43
GLY A 376
TYR A  45
 None
 0.59A 2vouA-2osyA:
undetectable		 2vouA-2osyA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		3 / 3 PRO A  43
GLY A 376
TYR A  45
 None
 0.71A 2vouB-2osyA:
undetectable		 2vouB-2osyA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		3 / 3 PRO A  43
GLY A 376
TYR A  45
 None
 0.72A 2vouC-2osyA:
undetectable		 2vouC-2osyA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		3 / 3 THR A 441
PRO A 440
THR A 472
 None
 0.82A 316dC-2osyA:
undetectable		 316dC-2osyA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		5 / 12 LEU A 249
GLY A 236
GLN A 240
VAL A 205
PHE A 194
 None
 1.38A 3gn8B-2osyA:
0.0		 3gn8B-2osyA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		4 / 7 HIS A 135
LEU A 249
PHE A 191
VAL A 187
 GLC  A 600 (-4.1A)
None
None
None
 1.10A 3jwqC-2osyA:
undetectable		 3jwqC-2osyA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		5 / 12 PHE A 191
ALA A 160
THR A 165
ILE A 143
MET A 188
 None
 1.27A 3ld6A-2osyA:
undetectable		 3ld6A-2osyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		5 / 12 PHE A 191
ALA A 160
THR A 165
ILE A 143
MET A 188
 None
 1.25A 3ld6B-2osyA:
undetectable		 3ld6B-2osyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		5 / 12 ARG A  93
ASP A 133
HIS A 135
ASP A 137
TYR A 306
 None
None
GLC  A 600 (-4.1A)
GLC  A 600 ( 2.4A)
GLC  A 600 ( 4.5A)
 1.49A 3lmyA-2osyA:
13.5		 3lmyA-2osyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		4 / 7 GLU A 206
ARG A 255
THR A 256
ALA A 259
 None
 1.31A 3mbgA-2osyA:
undetectable
3mbgB-2osyA:
undetectable		 3mbgA-2osyA:
14.59
3mbgB-2osyA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		4 / 6 TYR A 301
MET A 375
ILE A 347
SER A 284
 None
 1.16A 3pmzD-2osyA:
undetectable		 3pmzD-2osyA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		4 / 7 TRP A 195
PRO A 234
GLY A 241
PRO A 242
 None
 1.19A 3ucbB-2osyA:
undetectable		 3ucbB-2osyA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		3 / 3 ASN A  60
TRP A 382
ASP A 229
 None
GLC  A 600 ( 3.5A)
None
 1.16A 4a7tA-2osyA:
undetectable
4a7tF-2osyA:
undetectable		 4a7tA-2osyA:
14.73
4a7tF-2osyA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		4 / 8 GLY A 458
ALA A 459
ASP A 460
PRO A 433
 None
 0.81A 4eyrB-2osyA:
undetectable		 4eyrB-2osyA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		4 / 5 PRO A 292
ASP A 291
ILE A 260
VAL A 271
 None
 1.10A 4hytA-2osyA:
undetectable		 4hytA-2osyA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		3 / 3 LEU A  54
ARG A 411
ARG A  52
 None
 0.86A 4yiaB-2osyA:
undetectable		 4yiaB-2osyA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		4 / 5 ASP A 133
ARG A  93
LEU A 249
MET A 252
 None
 1.36A 5tuiB-2osyA:
0.0		 5tuiB-2osyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		5 / 9 TYR A 182
GLN A 240
GLY A 237
GLY A 236
MET A 188
 None
 0.86A 5v3cA-2osyA:
12.3		 5v3cA-2osyA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2osy ENDOGLYCOCERAMIDASE
II
(Rhodococcus
sp.) 		3 / 3 ASP A 133
LEU A  95
ARG A  99
 None
 0.82A 7dfrA-2osyA:
undetectable		 7dfrA-2osyA:
15.67