SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ot3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BLV_B_SAMB1281_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	2ot3	RAS-RELATED PROTEIN RAB-21 (Homo sapiens)	5 / 12	GLY B 77 GLY B 28 LEU B 84 HIS B 82 ASP B 74	None	1.16A	4blvB-2ot3B: undetectable	4blvB-2ot3B: 23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GRK_A_KTRA713_1 (LACTOTRANSFERRIN)	2ot3	RAS-RELATED PROTEIN RAB-21 (Homo sapiens)	4 / 5	THR B 75 GLY B 26 VAL B 98 TYR B 89	None	1.12A	4grkA-2ot3B: undetectable	4grkA-2ot3B: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DLV_B_5D5B927_1 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	2ot3	RAS-RELATED PROTEIN RAB-21 (Homo sapiens)	4 / 7	SER B 106 TYR B 99 LYS B 133 HIS B 160	None	1.09A	5dlvB-2ot3B: undetectable	5dlvB-2ot3B: 12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HRQ_C_IPHC101_0 (INSULIN A-CHAIN INSULIN B-CHAIN)	2ot3	RAS-RELATED PROTEIN RAB-21 (Homo sapiens)	4 / 5	ILE B 129 CYH B 128 LEU B 172 HIS B 158	None	1.46A	5hrqC-2ot3B: undetectable 5hrqD-2ot3B: undetectable 5hrqL-2ot3B: undetectable	5hrqC-2ot3B: 7.27 5hrqD-2ot3B: 14.29 5hrqL-2ot3B: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEP_A_VDYA201_2 (CDL2.3B)	2ot3	RAS-RELATED PROTEIN RAB-21 (Homo sapiens)	5 / 9	MET B 180 VAL B 36 LEU B 24 ILE B 72 TYR B 89	None	1.28A	5iepA-2ot3B: undetectable	5iepA-2ot3B: 21.39

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4BLV_B_SAMB1281_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","2ot3","RAS-RELATED PROTEIN RAB-21","Homo sapiens",5,"GLY B  77;GLY B  28;LEU B  84;HIS B  82;ASP B  74","None","1.16A","4blvB-2ot3B:undetectable","4blvB-2ot3B:23.08"],["4GRK_A_KTRA713_1","LACTOTRANSFERRIN","2ot3","RAS-RELATED PROTEIN RAB-21","Homo sapiens",4,"THR B  75;GLY B  26;VAL B  98;TYR B  89","None","1.12A","4grkA-2ot3B:undetectable","4grkA-2ot3B:21.47"],["5DLV_B_5D5B927_1","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","2ot3","RAS-RELATED PROTEIN RAB-21","Homo sapiens",4,"SER B 106;TYR B  99;LYS B 133;HIS B 160","None","1.09A","5dlvB-2ot3B:undetectable","5dlvB-2ot3B:12.89"],["5HRQ_C_IPHC101_0","INSULIN A-CHAIN;INSULIN B-CHAIN","2ot3","RAS-RELATED PROTEIN RAB-21","Homo sapiens",4,"ILE B 129;CYH B 128;LEU B 172;HIS B 158","None","1.46A","5hrqC-2ot3B:undetectable;5hrqD-2ot3B:undetectable;5hrqL-2ot3B:undetectable","5hrqC-2ot3B:7.27;5hrqD-2ot3B:14.29;5hrqL-2ot3B:14.29"],["5IEP_A_VDYA201_2","CDL2.3B","2ot3","RAS-RELATED PROTEIN RAB-21","Homo sapiens",5,"MET B 180;VAL B  36;LEU B  24;ILE B  72;TYR B  89","None","1.28A","5iepA-2ot3B:undetectable","5iepA-2ot3B:21.39"]]