SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2otb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		4 / 6 TYR A  91
GLU A 148
ILE A 122
TYR A 120
 None
None
None
PIA  A  66 ( 4.7A)
 1.09A 1maaB-2otbA:
undetectable
1maaD-2otbA:
undetectable		 1maaB-2otbA:
16.93
1maaD-2otbA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		3 / 3 PHE A  56
LEU A  61
LEU A 124
 None
 0.66A 1mx1E-2otbA:
undetectable		 1mx1E-2otbA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		3 / 3 ARG A  70
ILE A 111
TRP A  93
 PIA  A  66 ( 4.1A)
None
PIA  A  66 ( 4.1A)
 1.09A 1nodB-2otbA:
undetectable		 1nodB-2otbA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		4 / 4 ASP A  59
LEU A 166
LEU A 141
LEU A 165
 None
 1.24A 1u18A-2otbA:
undetectable		 1u18A-2otbA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		5 / 12 PHE A  65
LEU A  46
GLY A  33
GLY A  31
SER A 117
 None
 1.38A 3dh0A-2otbA:
undetectable		 3dh0A-2otbA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		5 / 12 LEU A 165
SER A  57
PHE A 177
VAL A 105
ASN A  63
 None
None
None
None
PIA  A  66 ( 4.5A)
 1.21A 3nhxA-2otbA:
0.0		 3nhxA-2otbA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		4 / 6 ARG A  70
ASN A  81
GLY A   6
PRO A  37
 PIA  A  66 ( 4.1A)
None
None
None
 1.10A 4l1aB-2otbA:
undetectable		 4l1aB-2otbA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		4 / 5 GLY A  40
SER A 216
ALA A 217
PHE A  72
 None
 1.04A 4m93B-2otbA:
undetectable
4m93C-2otbA:
undetectable		 4m93B-2otbA:
18.44
4m93C-2otbA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		4 / 8 ASN A  63
PHE A 177
TRP A  93
TYR A 181
 PIA  A  66 ( 4.5A)
None
PIA  A  66 ( 4.1A)
None
 1.20A 5amkA-2otbA:
undetectable		 5amkA-2otbA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		5 / 12 GLU A 215
ARG A  70
MET A  18
GLY A  31
LEU A  46
 PIA  A  66 ( 3.5A)
PIA  A  66 ( 4.1A)
None
None
None
 1.14A 5gs4A-2otbA:
undetectable		 5gs4A-2otbA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		3 / 3 TYR A 120
TYR A  82
SER A  86
 PIA  A  66 ( 4.7A)
None
None
 0.98A 5iktB-2otbA:
undetectable		 5iktB-2otbA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2otb GFP-LIKE FLUORESCENT
CHROMOPROTEIN CFP484
(Clavularia
sp.) 		4 / 8 SER A 146
HIS A 163
PHE A 177
THR A  62
 PIA  A  66 ( 2.7A)
PIA  A  66 ( 3.6A)
None
None
 1.23A 5u6nA-2otbA:
undetectable		 5u6nA-2otbA:
19.22