SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2otd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		5 / 12 LEU A  52
LEU A 136
THR A 125
LEU A 145
ALA A  42
 None
 0.99A 1bzfA-2otdA:
undetectable		 1bzfA-2otdA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 8 GLY A 241
THR A 214
ILE A 237
ASN A 216
 None
 1.06A 2a8tB-2otdA:
undetectable		 2a8tB-2otdA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		3 / 3 GLU A 114
HIS A  12
GLU A  39
 PO4  A 301 (-3.4A)
PO4  A 301 (-4.0A)
PO4  A 301 (-3.9A)
 0.69A 2x45B-2otdA:
undetectable		 2x45B-2otdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		3 / 3 GLU A 114
HIS A  12
GLU A  39
 PO4  A 301 (-3.4A)
PO4  A 301 (-4.0A)
PO4  A 301 (-3.9A)
 0.69A 2x45C-2otdA:
undetectable		 2x45C-2otdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 6 ILE A  27
LYS A  32
ILE A 237
HIS A  12
 None
None
None
PO4  A 301 (-4.0A)
 1.02A 3eteA-2otdA:
undetectable
3eteE-2otdA:
undetectable		 3eteA-2otdA:
18.45
3eteE-2otdA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 7 LYS A  32
ILE A 237
HIS A  12
ILE A  27
 None
None
PO4  A 301 (-4.0A)
None
 1.03A 3eteD-2otdA:
undetectable
3eteF-2otdA:
undetectable		 3eteD-2otdA:
18.45
3eteF-2otdA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 5 GLY A 122
GLU A 149
GLY A 120
PRO A 117
 None
 0.79A 3onnA-2otdA:
undetectable		 3onnA-2otdA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 7 ALA A 236
ILE A 237
HIS A  35
GLY A 241
 None
 0.82A 3v4tH-2otdA:
undetectable		 3v4tH-2otdA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 7 ASP A  41
ASP A 235
ASN A  22
GLU A 114
 PO4  A 301 (-3.8A)
None
None
PO4  A 301 (-3.4A)
 1.20A 4fevB-2otdA:
undetectable		 4fevB-2otdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 7 ASP A  41
ASP A 235
ASN A  22
GLU A 114
 PO4  A 301 (-3.8A)
None
None
PO4  A 301 (-3.4A)
 1.22A 4fewB-2otdA:
undetectable		 4fewB-2otdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		3 / 3 TYR A 213
ARG A  13
HIS A  54
 PO4  A 301 (-4.0A)
PO4  A 301 (-4.5A)
PO4  A 301 ( 4.9A)
 0.98A 4fubA-2otdA:
undetectable		 4fubA-2otdA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 6 ASP A  41
ASP A 235
ASN A  22
GLU A 114
 PO4  A 301 (-3.8A)
None
None
PO4  A 301 (-3.4A)
 1.21A 4gkhJ-2otdA:
undetectable		 4gkhJ-2otdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		5 / 10 GLY A 166
ASN A 112
ILE A 150
LEU A 167
LEU A 153
 None
 1.20A 4xj7A-2otdA:
undetectable
4xj7B-2otdA:
undetectable		 4xj7A-2otdA:
22.26
4xj7B-2otdA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		5 / 12 GLY A  48
SER A  45
LYS A  46
GLU A 149
GLU A 114
 None
None
None
None
PO4  A 301 (-3.4A)
 1.22A 5nwuA-2otdA:
undetectable		 5nwuA-2otdA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 6 LEU A 153
TYR A 213
ASP A  41
GLU A 114
 None
PO4  A 301 (-4.0A)
PO4  A 301 (-3.8A)
PO4  A 301 (-3.4A)
 0.95A 6djzC-2otdA:
undetectable		 6djzC-2otdA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 8 ASP A  55
ARG A  60
ASN A 112
TYR A 213
 None
None
None
PO4  A 301 (-4.0A)
 1.16A 6hisA-2otdA:
undetectable
6hisB-2otdA:
undetectable		 6hisA-2otdA:
12.56
6hisB-2otdA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 8 ASP A  55
ARG A  60
ASN A 112
TYR A 213
 None
None
None
PO4  A 301 (-4.0A)
 1.18A 6hisB-2otdA:
undetectable
6hisC-2otdA:
undetectable		 6hisB-2otdA:
12.56
6hisC-2otdA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 2otd GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE
(Shigella
flexneri) 		4 / 8 ASP A  55
ARG A  60
ASN A 112
TYR A 213
 None
None
None
PO4  A 301 (-4.0A)
 1.15A 6hisD-2otdA:
undetectable
6hisE-2otdA:
undetectable		 6hisD-2otdA:
12.56
6hisE-2otdA:
12.56