SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2otm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2otm HYPOTHETICAL PROTEIN
(Shewanella
oneidensis) 		4 / 8 LEU A  95
ARG A 128
PHE A 123
GLY A 124
 None
 1.03A 1fapB-2otmA:
undetectable		 1fapB-2otmA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 2otm HYPOTHETICAL PROTEIN
(Shewanella
oneidensis) 		5 / 12 LEU A  99
VAL A  61
ASP A 113
GLY A 114
THR A  72
 None
 1.08A 1r9oA-2otmA:
undetectable		 1r9oA-2otmA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 2otm HYPOTHETICAL PROTEIN
(Shewanella
oneidensis) 		4 / 4 GLY A  64
TYR A  65
GLY A 114
ASP A 113
 None
 0.93A 3kl3A-2otmA:
undetectable		 3kl3A-2otmA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2otm HYPOTHETICAL PROTEIN
(Shewanella
oneidensis) 		4 / 8 LEU A  86
LEU A 118
ILE A  89
PHE A 123
 None
 0.83A 3ln1A-2otmA:
undetectable		 3ln1A-2otmA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2otm HYPOTHETICAL PROTEIN
(Shewanella
oneidensis) 		4 / 7 LEU A  86
LEU A 118
ILE A  89
PHE A 123
 None
 0.81A 3ln1B-2otmA:
undetectable		 3ln1B-2otmA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2otm HYPOTHETICAL PROTEIN
(Shewanella
oneidensis) 		3 / 3 ALA A  20
VAL A  19
GLN A  78
 None
 0.75A 3of4B-2otmA:
undetectable		 3of4B-2otmA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 2otm HYPOTHETICAL PROTEIN
(Shewanella
oneidensis) 		5 / 12 LEU A  79
LEU A 119
ALA A  75
THR A  72
LEU A  73
 None
 0.86A 3r9cA-2otmA:
undetectable		 3r9cA-2otmA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 2otm HYPOTHETICAL PROTEIN
(Shewanella
oneidensis) 		3 / 3 LYS A 110
PRO A 109
LEU A 112
 None
ACT  A 156 (-4.1A)
None
 0.87A 3tpxE-2otmA:
undetectable		 3tpxE-2otmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2otm HYPOTHETICAL PROTEIN
(Shewanella
oneidensis) 		5 / 9 VAL A 101
LEU A  99
GLY A 114
LEU A 112
CYH A  68
 None
 1.27A 6czmD-2otmA:
undetectable
6czmE-2otmA:
undetectable		 6czmD-2otmA:
19.61
6czmE-2otmA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2otm HYPOTHETICAL PROTEIN
(Shewanella
oneidensis) 		4 / 6 LEU A 119
ALA A 115
LEU A  79
THR A  38
 None
 0.83A 6f88B-2otmA:
undetectable		 6f88B-2otmA:
24.03