SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ou2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		4 / 8 TYR A 198
TYR A 209
LEU A 224
GLU A 212
 None
 1.01A 1i7zA-2ou2A:
undetectable		 1i7zA-2ou2A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		3 / 3 LYS A 399
ILE A 389
THR A 369
 None
 0.68A 1rx3A-2ou2A:
undetectable		 1rx3A-2ou2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		5 / 11 LEU A 210
LEU A 267
VAL A 207
TYR A 198
LYS A 216
 None
 1.41A 1y4lB-2ou2A:
undetectable		 1y4lB-2ou2A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		4 / 8 TYR A 365
ILE A 370
ILE A 398
ILE A 392
 None
 0.81A 2bu8A-2ou2A:
undetectable		 2bu8A-2ou2A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		3 / 3 LEU A 441
TYR A 329
GLY A 301
 None
 0.63A 2ocuA-2ou2A:
undetectable		 2ocuA-2ou2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		5 / 9 TYR A 302
THR A 281
PHE A 271
LEU A 215
LEU A 267
 ALY  A 275 ( 4.8A)
None
None
None
None
 1.50A 2zb8A-2ou2A:
0.0		 2zb8A-2ou2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		3 / 3 TYR A 194
ASP A 356
ASP A 273
 None
 0.84A 3r24A-2ou2A:
undetectable		 3r24A-2ou2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		3 / 3 LYS A 399
ILE A 389
THR A 369
 None
 0.71A 4gh8A-2ou2A:
undetectable		 4gh8A-2ou2A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		4 / 6 GLU A 212
PHE A 297
TYR A 292
HIS A 298
 None
 1.44A 4uciA-2ou2A:
undetectable		 4uciA-2ou2A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		4 / 7 GLU A 212
PHE A 297
TYR A 292
HIS A 298
 None
 1.44A 4uciB-2ou2A:
undetectable		 4uciB-2ou2A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		5 / 12 GLY A 254
THR A 281
PHE A 303
GLU A 251
VAL A 288
 None
 1.22A 5hw4C-2ou2A:
undetectable		 5hw4C-2ou2A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		4 / 5 LEU A 185
CYH A 211
CYH A 231
LEU A 233
 None
ZN  A 490 (-2.3A)
ZN  A 490 (-2.4A)
None
 1.37A 5mafA-2ou2A:
undetectable		 5mafA-2ou2A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP
(Homo
sapiens) 		5 / 12 LEU A 272
TYR A 302
GLY A 301
ALA A 268
GLU A 291
 ALY  A 275 (-4.8A)
ALY  A 275 ( 4.8A)
None
ALY  A 275 ( 4.1A)
None
 1.25A 5x6yC-2ou2A:
undetectable		 5x6yC-2ou2A:
15.67