SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ouc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 8 VAL A 212
VAL A 255
LEU A 215
HIS A 193
 None
 0.79A 2ddwA-2oucA:
undetectable		 2ddwA-2oucA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 4 LEU A 155
PRO A 152
LEU A 269
ARG A 178
 None
 1.29A 2hrcA-2oucA:
undetectable		 2hrcA-2oucA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 4 LEU A 155
PRO A 152
LEU A 269
ARG A 178
 None
 1.44A 2pnjB-2oucA:
undetectable		 2pnjB-2oucA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		3 / 3 ARG A 202
GLN A 250
PRO A 251
 None
 0.97A 2qhfA-2oucA:
undetectable		 2qhfA-2oucA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		5 / 10 VAL A 192
ILE A 150
LEU A 259
VAL A 255
VAL A 212
 None
 1.06A 3gwxA-2oucA:
undetectable		 3gwxA-2oucA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 4 LEU A 155
PRO A 152
LEU A 269
ARG A 178
 None
 1.24A 3hcoB-2oucA:
undetectable		 3hcoB-2oucA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		5 / 12 ALA A 191
ILE A 174
ASN A 282
LEU A 283
MET A 159
 None
 1.16A 4r38A-2oucA:
undetectable		 4r38A-2oucA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		5 / 12 ALA A 191
ILE A 174
ASN A 282
LEU A 283
MET A 159
 None
 1.15A 4r38C-2oucA:
undetectable		 4r38C-2oucA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		5 / 12 ALA A 191
ILE A 174
ASN A 282
LEU A 283
MET A 159
 None
 1.18A 4r38D-2oucA:
undetectable		 4r38D-2oucA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 7 SER A 186
LEU A 273
ILE A 234
LEU A 269
 None
 0.87A 5te8A-2oucA:
undetectable		 5te8A-2oucA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		3 / 3 ILE A 175
VAL A 255
PRO A 251
 None
 0.71A 5uunA-2oucA:
undetectable		 5uunA-2oucA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 6 ILE A 150
LEU A 283
PHE A 276
HIS A 280
 None
 1.01A 5vkqB-2oucA:
undetectable
5vkqC-2oucA:
undetectable		 5vkqB-2oucA:
5.80
5vkqC-2oucA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10
(Homo
sapiens) 		4 / 6 ILE A 150
LEU A 283
PHE A 276
HIS A 280
 None
 1.01A 5vkqC-2oucA:
undetectable
5vkqD-2oucA:
undetectable		 5vkqC-2oucA:
5.80
5vkqD-2oucA:
5.80