SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2oum 50S RIBOSOMAL
PROTEIN L1
(Thermus
thermophilus) 		3 / 3 HIS A 199
ILE A 171
LEU A 209
 None
 0.73A 2kceA-2oumA:
undetectable		 2kceA-2oumA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2oum 50S RIBOSOMAL
PROTEIN L1
(Thermus
thermophilus) 		4 / 7 LEU A  47
PHE A 208
LEU A 196
PHE A 163
 None
 1.04A 3asnP-2oumA:
undetectable
3asnW-2oumA:
undetectable		 3asnP-2oumA:
16.73
3asnW-2oumA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2oum 50S RIBOSOMAL
PROTEIN L1
(Thermus
thermophilus) 		5 / 10 ILE A 224
ILE A  22
PRO A  65
VAL A 175
LEU A 209
 None
 1.20A 3elzC-2oumA:
undetectable		 3elzC-2oumA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2oum 50S RIBOSOMAL
PROTEIN L1
(Thermus
thermophilus) 		5 / 10 ASP A 166
ALA A 170
GLY A 169
VAL A  58
HIS A 172
 None
 1.39A 4c5nD-2oumA:
undetectable		 4c5nD-2oumA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 2oum 50S RIBOSOMAL
PROTEIN L1
(Thermus
thermophilus) 		4 / 8 ALA A 186
HIS A  66
ASN A 188
ARG A 190
 None
 1.24A 5db5A-2oumA:
undetectable
5db5B-2oumA:
undetectable		 5db5A-2oumA:
15.97
5db5B-2oumA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2oum 50S RIBOSOMAL
PROTEIN L1
(Thermus
thermophilus) 		4 / 4 LEU A 185
ARG A 190
ILE A 189
ILE A  22
 None
 1.14A 5dzk2-2oumA:
undetectable
5dzkM-2oumA:
undetectable
5dzkN-2oumA:
undetectable		 5dzk2-2oumA:
18.18
5dzkM-2oumA:
19.91
5dzkN-2oumA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2oum 50S RIBOSOMAL
PROTEIN L1
(Thermus
thermophilus) 		3 / 3 GLY A 159
THR A 217
PRO A 174
 None
 0.66A 5v5zA-2oumA:
undetectable		 5v5zA-2oumA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2oum 50S RIBOSOMAL
PROTEIN L1
(Thermus
thermophilus) 		4 / 5 LEU A  47
PHE A 208
LEU A 196
PHE A 163
 None
 1.05A 5x19C-2oumA:
undetectable
5x19J-2oumA:
undetectable		 5x19C-2oumA:
16.73
5x19J-2oumA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 2oum 50S RIBOSOMAL
PROTEIN L1
(Thermus
thermophilus) 		5 / 11 ILE A 193
HIS A 199
GLY A  60
PHE A 192
ALA A 173
 None
 1.26A 6ieyA-2oumA:
undetectable
6ieyB-2oumA:
undetectable		 6ieyA-2oumA:
17.35
6ieyB-2oumA:
17.35