SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		5 / 11 LEU A 119
VAL A 101
ALA A 100
LEU A 103
LEU A 116
 None
 1.34A 2c12F-2ouxA:
undetectable		 2c12F-2ouxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		4 / 7 LEU A  57
LEU A  53
PHE A  26
LEU A  31
 None
 0.89A 2vq5B-2ouxA:
undetectable		 2vq5B-2ouxA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		5 / 11 VAL A 155
ILE A 202
ASN A 207
ILE A 188
SER A 189
 None
 1.18A 3kpcA-2ouxA:
15.4		 3kpcA-2ouxA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		5 / 12 VAL A 155
ILE A 202
ASN A 207
ILE A 188
SER A 189
 None
 1.15A 3kpdB-2ouxA:
14.9		 3kpdB-2ouxA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		4 / 7 TYR A  54
LEU A  31
LEU A  53
PHE A  66
 None
 1.25A 3nk2X-2ouxA:
undetectable		 3nk2X-2ouxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		4 / 5 TYR A  79
SER A  44
ASP A  67
ILE A  35
 None
 1.29A 3uj7B-2ouxA:
undetectable		 3uj7B-2ouxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		5 / 7 ASP A 250
ASP A  98
ASN A  99
GLU A  71
GLU A 170
 MG  A 406 ( 4.5A)
MG  A 406 (-2.7A)
MG  A 406 ( 4.4A)
MG  A 409 (-2.5A)
MG  A 406 ( 3.9A)
 1.43A 4feuB-2ouxA:
undetectable		 4feuB-2ouxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		5 / 8 ASP A 250
ASP A  98
ASN A  99
GLU A  71
GLU A 170
 MG  A 406 ( 4.5A)
MG  A 406 (-2.7A)
MG  A 406 ( 4.4A)
MG  A 409 (-2.5A)
MG  A 406 ( 3.9A)
 1.50A 4feuF-2ouxA:
undetectable		 4feuF-2ouxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		4 / 6 ASP A  67
ALA A 100
THR A 143
TYR A  96
 None
None
MG  A 406 ( 4.9A)
None
 1.14A 4w5qA-2ouxA:
undetectable		 4w5qA-2ouxA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		4 / 6 ASP A  67
ALA A 100
THR A 143
TYR A  96
 None
None
MG  A 406 ( 4.9A)
None
 1.12A 4w5rA-2ouxA:
undetectable		 4w5rA-2ouxA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		4 / 6 ASP A  67
ALA A 100
THR A 143
TYR A  96
 None
None
MG  A 406 ( 4.9A)
None
 1.10A 4w5tA-2ouxA:
undetectable		 4w5tA-2ouxA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		4 / 6 ASP A  67
ALA A 100
THR A 143
TYR A  96
 None
None
MG  A 406 ( 4.9A)
None
 1.12A 4z4cA-2ouxA:
undetectable		 4z4cA-2ouxA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		4 / 5 ASP A  67
ALA A 100
THR A 143
TYR A  96
 None
None
MG  A 406 ( 4.9A)
None
 1.12A 4z4gA-2ouxA:
undetectable		 4z4gA-2ouxA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		4 / 5 ASP A  67
ALA A 100
THR A 143
TYR A  96
 None
None
MG  A 406 ( 4.9A)
None
 1.10A 4z4hA-2ouxA:
undetectable		 4z4hA-2ouxA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		4 / 6 ASP A  67
ALA A 100
THR A 143
TYR A  96
 None
None
MG  A 406 ( 4.9A)
None
 1.11A 4z4iA-2ouxA:
undetectable		 4z4iA-2ouxA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2oux MAGNESIUM
TRANSPORTER
(Enterococcus
faecalis) 		3 / 3 LEU A 232
ASP A 254
ILE A 141
 None
 0.61A 6dh0B-2ouxA:
undetectable		 6dh0B-2ouxA:
14.44