SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ovj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 4 THR A 379
LEU A 378
VAL A 483
LEU A 480
 None
 1.10A 1fbmB-2ovjA:
undetectable		 1fbmB-2ovjA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 11 MET A 491
GLY A 501
VAL A 528
GLU A 529
ILE A 504
 None
 1.20A 1pk9C-2ovjA:
undetectable		 1pk9C-2ovjA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 9 MET A 491
GLY A 501
VAL A 528
GLU A 529
ILE A 504
 None
 1.21A 1pw7B-2ovjA:
undetectable		 1pw7B-2ovjA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 11 MET A 491
GLY A 501
VAL A 528
GLU A 529
ILE A 504
 None
 1.23A 1vhwA-2ovjA:
undetectable
1vhwD-2ovjA:
undetectable		 1vhwA-2ovjA:
22.52
1vhwD-2ovjA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 11 MET A 491
GLY A 501
VAL A 528
GLU A 529
ILE A 504
 None
 1.23A 1vhwC-2ovjA:
undetectable
1vhwE-2ovjA:
undetectable		 1vhwC-2ovjA:
22.52
1vhwE-2ovjA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 11 MET A 491
GLY A 501
VAL A 528
GLU A 529
ILE A 504
 None
 1.23A 1vhwA-2ovjA:
undetectable
1vhwD-2ovjA:
undetectable		 1vhwA-2ovjA:
22.52
1vhwD-2ovjA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 11 MET A 491
GLY A 501
VAL A 528
GLU A 529
ILE A 504
 None
 1.23A 1vhwC-2ovjA:
undetectable
1vhwE-2ovjA:
undetectable		 1vhwC-2ovjA:
22.52
1vhwE-2ovjA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 7 MET A 350
ARG A 437
PRO A 363
MET A 361
 None
 1.17A 2hrcA-2ovjA:
undetectable		 2hrcA-2ovjA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1603_0
(FERROCHELATASE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 MET A 350
ARG A 437
PRO A 363
MET A 361
 None
 1.29A 2hrcB-2ovjA:
0.0		 2hrcB-2ovjA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 7 MET A 350
ARG A 437
PRO A 363
MET A 361
 None
 1.11A 2pnjB-2ovjA:
undetectable		 2pnjB-2ovjA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ALA A 497
GLY A 501
VAL A 505
LEU A 532
 None
 0.85A 2uyqA-2ovjA:
undetectable		 2uyqA-2ovjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 459
ARG A 470
SER A 533
VAL A 462
 None
 1.35A 2y05A-2ovjA:
undetectable
2y05B-2ovjA:
undetectable		 2y05A-2ovjA:
21.69
2y05B-2ovjA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 6 MET A 350
ARG A 437
PRO A 363
MET A 361
 None
 1.10A 3aqiA-2ovjA:
undetectable		 3aqiA-2ovjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 11 MET A 491
GLY A 501
VAL A 528
GLU A 529
ILE A 504
 None
 1.15A 3uawA-2ovjA:
undetectable		 3uawA-2ovjA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 10 MET A 491
GLY A 501
VAL A 528
GLU A 529
ILE A 504
 None
 1.13A 3uayA-2ovjA:
undetectable		 3uayA-2ovjA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 5 MET A 350
ARG A 437
PRO A 363
MET A 361
 None
 1.11A 4klaB-2ovjA:
0.0		 4klaB-2ovjA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 9 ALA A 468
LEU A 429
LEU A 426
ILE A 365
 None
 0.93A 4xtaA-2ovjA:
undetectable		 4xtaA-2ovjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 471
VAL A 355
LEU A 351
 None
 0.66A 5e5jB-2ovjA:
undetectable		 5e5jB-2ovjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2ovj RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		5 / 10 MET A 491
GLY A 501
VAL A 528
GLU A 529
ILE A 504
 None
 1.17A 5i3cB-2ovjA:
undetectable		 5i3cB-2ovjA:
23.26