SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ow4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		3 / 3 PHE A 195
LEU A   9
MET A  42
 None
 0.86A 1mx1D-2ow4A:
undetectable		 1mx1D-2ow4A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		3 / 3 ALA A 177
VAL A  89
TRP A  88
 None
 0.94A 1ng8A-2ow4A:
undetectable		 1ng8A-2ow4A:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		3 / 3 ALA A 177
VAL A  89
TRP A  88
 None
 0.94A 1ng8B-2ow4A:
undetectable		 1ng8B-2ow4A:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		6 / 12 GLY A 227
GLY A  98
ILE A 210
LEU A 156
VAL A 170
ALA A  95
 MMA  A 242 (-3.5A)
MMA  A 242 ( 3.1A)
None
None
None
None
 1.44A 1v2xA-2ow4A:
undetectable		 1v2xA-2ow4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 8 LEU A  61
PHE A 191
PHE A 111
SER A 215
 None
 1.01A 1wrlC-2ow4A:
undetectable
1wrlD-2ow4A:
undetectable		 1wrlC-2ow4A:
18.57
1wrlD-2ow4A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 8 LEU A 156
ILE A 210
LEU A  93
LEU A 154
 None
 0.65A 2xfhA-2ow4A:
undetectable		 2xfhA-2ow4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 9 ALA A 146
ILE A 221
THR A 226
SER A 225
PHE A 233
 None
None
MAN  A 241 (-3.3A)
None
None
 1.48A 3hbbB-2ow4A:
undetectable		 3hbbB-2ow4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 8 LEU A 230
GLY A 144
ALA A 146
ILE A 106
 None
 0.81A 3jusA-2ow4A:
undetectable		 3jusA-2ow4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 8 LEU A 230
GLY A 144
ALA A 146
ILE A 106
 None
 0.81A 3jusA-2ow4A:
undetectable		 3jusA-2ow4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 8 LEU A 230
GLY A 144
ALA A 146
ILE A 106
 None
 0.82A 3jusB-2ow4A:
undetectable		 3jusB-2ow4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		3 / 3 PRO A 165
SER A 201
ASN A 104
 None
 0.79A 3lslG-2ow4A:
undetectable		 3lslG-2ow4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 7 PHE A 111
SER A 215
VAL A   5
VAL A  89
 None
 1.29A 3n61A-2ow4A:
undetectable
3n61B-2ow4A:
undetectable		 3n61A-2ow4A:
20.37
3n61B-2ow4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 LEU A 232
GLY A 171
LEU A 230
GLY A 227
PRO A 222
 None
None
None
MMA  A 242 (-3.5A)
None
 1.16A 4blvA-2ow4A:
undetectable		 4blvA-2ow4A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 7 ALA A 211
ALA A  63
GLY A  26
ILE A  25
 None
 0.60A 4eatA-2ow4A:
undetectable		 4eatA-2ow4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 VAL A  65
LEU A  93
LEU A 156
ILE A 210
ILE A 199
 None
 0.95A 4y0rA-2ow4A:
undetectable		 4y0rA-2ow4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 VAL A  65
LEU A  93
LEU A 156
ILE A 210
ILE A 199
 None
 0.95A 4y0sA-2ow4A:
undetectable		 4y0sA-2ow4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 0.96A 4zdyA-2ow4A:
undetectable		 4zdyA-2ow4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 1.02A 4ze2A-2ow4A:
undetectable		 4ze2A-2ow4A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 6 LEU A 198
LEU A 107
SER A 108
VAL A  65
 None
 1.18A 5a6iA-2ow4A:
undetectable		 5a6iA-2ow4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 1.05A 5eqbA-2ow4A:
undetectable		 5eqbA-2ow4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		3 / 3 GLY A 209
THR A  97
ASN A 104
 None
 0.65A 5odiG-2ow4A:
undetectable		 5odiG-2ow4A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 4 GLU A 102
THR A 103
THR A 196
LEU A  93
 None
 1.47A 5v96A-2ow4A:
undetectable		 5v96A-2ow4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 4 GLU A 102
THR A 103
THR A 196
LEU A  93
 None
 1.47A 5v96C-2ow4A:
0.0		 5v96C-2ow4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 4 GLU A 102
THR A 103
THR A 196
LEU A  93
 None
 1.47A 5v96D-2ow4A:
undetectable		 5v96D-2ow4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		3 / 3 TYR A 176
ALA A 173
LEU A 142
 None
 0.69A 6ag0C-2ow4A:
undetectable		 6ag0C-2ow4A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		4 / 6 SER A 108
ALA A 193
SER A 110
ALA A  50
 None
 0.99A 6bocA-2ow4A:
undetectable
6bocB-2ow4A:
undetectable
6bocC-2ow4A:
undetectable
6bocD-2ow4A:
undetectable		 6bocA-2ow4A:
7.83
6bocB-2ow4A:
7.83
6bocC-2ow4A:
7.83
6bocD-2ow4A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2ow4 CANAVALIA MARITIMA
LECTIN
(Canavalia
rosea) 		5 / 12 GLY A  98
ILE A  52
GLY A  92
LEU A 156
THR A 226
 MMA  A 242 ( 3.1A)
None
None
None
MAN  A 241 (-3.3A)
 0.99A 6e8qA-2ow4A:
undetectable		 6e8qA-2ow4A:
16.90