SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2owl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC
(Escherichia
coli) 		5 / 12 LEU A 293
GLY A 296
LEU A 289
ALA A 186
SER A 249
 None
 1.12A 1dfoA-2owlA:
undetectable		 1dfoA-2owlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC
(Escherichia
coli) 		5 / 12 LEU A 293
GLY A 296
LEU A 289
ALA A 186
SER A 249
 None
 1.13A 1dfoB-2owlA:
undetectable		 1dfoB-2owlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC
(Escherichia
coli) 		5 / 12 LEU A 293
GLY A 296
LEU A 289
ALA A 186
SER A 249
 None
 1.12A 1dfoC-2owlA:
undetectable		 1dfoC-2owlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC
(Escherichia
coli) 		5 / 12 LEU A 293
GLY A 296
LEU A 289
ALA A 186
SER A 249
 None
 1.12A 1dfoD-2owlA:
undetectable		 1dfoD-2owlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC
(Escherichia
coli) 		5 / 12 LEU A 293
GLY A 296
LEU A 289
ALA A 186
SER A 249
 None
 1.16A 1eqbD-2owlA:
undetectable		 1eqbD-2owlA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC
(Escherichia
coli) 		5 / 11 LEU A  12
ALA A  20
MET A  23
LEU A 158
HIS A  58
 None
 1.35A 1iiuA-2owlA:
undetectable		 1iiuA-2owlA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC
(Escherichia
coli) 		4 / 7 LEU A   7
ILE A 280
THR A 283
MET A   1
 None
 1.27A 1kglA-2owlA:
0.6		 1kglA-2owlA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC
(Escherichia
coli) 		3 / 3 ASP A 140
LYS A 251
ARG A 252
 None
 1.10A 1ra8A-2owlA:
undetectable		 1ra8A-2owlA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC
(Escherichia
coli) 		5 / 9 VAL A 163
VAL A 164
VAL A 139
ILE A 137
GLY A 135
 None
 0.82A 4fwdA-2owlA:
undetectable		 4fwdA-2owlA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC
(Escherichia
coli) 		4 / 6 LEU A   7
ILE A 280
THR A 283
MET A   1
 None
 1.24A 5ljeA-2owlA:
undetectable		 5ljeA-2owlA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2owl RECOMBINATION-ASSOCI
ATED PROTEIN RDGC
(Escherichia
coli) 		5 / 10 GLY A 188
TRP A 236
LEU A 293
GLY A 296
LEU A 151
 None
 1.35A 6hqbA-2owlA:
undetectable
6hqbJ-2owlA:
undetectable		 6hqbA-2owlA:
13.99
6hqbJ-2owlA:
8.58