SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2owm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		4 / 7 GLN A 145
THR A 400
SER A 393
TYR A 397
 None
 1.40A 1eiiA-2owmA:
undetectable		 1eiiA-2owmA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		4 / 4 ILE A 164
LEU A 205
VAL A 191
ILE A 243
 None
 0.67A 1fm6D-2owmA:
undetectable		 1fm6D-2owmA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		4 / 8 VAL A  62
GLU A  63
SER A 103
ILE A 392
 None
 0.89A 1pk7B-2owmA:
undetectable		 1pk7B-2owmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		3 / 3 ARG A 294
VAL A  40
THR A 415
 None
 0.65A 2nmzA-2owmA:
undetectable		 2nmzA-2owmA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		3 / 3 ARG A 294
VAL A  40
THR A 415
 None
 0.60A 2nnkA-2owmA:
undetectable		 2nnkA-2owmA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		4 / 6 SER A 148
SER A 151
GLY A 302
GLY A 144
 ADP  A1002 (-3.4A)
MG  A1001 ( 1.9A)
None
None
 0.76A 2otvA-2owmA:
undetectable		 2otvA-2owmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		4 / 8 SER A 148
SER A 151
GLY A 302
GLY A 144
 ADP  A1002 (-3.4A)
MG  A1001 ( 1.9A)
None
None
 0.70A 2vinA-2owmA:
undetectable		 2vinA-2owmA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		3 / 3 MET A 247
VAL A 208
GLU A 195
 None
 0.63A 2x9gA-2owmA:
undetectable		 2x9gA-2owmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		3 / 3 ARG A 294
VAL A  40
THR A 415
 None
 0.65A 3k4vA-2owmA:
undetectable		 3k4vA-2owmA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		3 / 3 ARG A 294
VAL A  40
THR A 415
 None
 0.67A 3k4vD-2owmA:
undetectable		 3k4vD-2owmA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		3 / 3 ARG A 294
VAL A  40
THR A 415
 None
 0.68A 3nduD-2owmA:
undetectable		 3nduD-2owmA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		3 / 3 ARG A 294
VAL A  40
THR A 415
 None
 0.58A 3pwrA-2owmA:
undetectable		 3pwrA-2owmA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		4 / 6 SER A 148
SER A 151
GLY A 302
GLY A 144
 ADP  A1002 (-3.4A)
MG  A1001 ( 1.9A)
None
None
 0.68A 3rxfA-2owmA:
undetectable		 3rxfA-2owmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		3 / 3 ARG A 294
VAL A  40
THR A 415
 None
 0.64A 3tl9A-2owmA:
undetectable		 3tl9A-2owmA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		3 / 3 ARG A  56
GLU A  59
THR A 395
 None
 0.91A 3v4tA-2owmA:
0.5		 3v4tA-2owmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		3 / 3 PHE A 141
TYR A 406
TYR A 143
 None
 1.10A 4ffwA-2owmA:
undetectable		 4ffwA-2owmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		3 / 3 HIS A 269
VAL A 229
LEU A 375
 None
 0.71A 4m2vA-2owmA:
undetectable		 4m2vA-2owmA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		4 / 5 SER A 106
ARG A  41
GLY A 125
GLU A 127
 ADP  A1002 (-4.7A)
None
None
None
 1.16A 5cdqA-2owmA:
undetectable
5cdqB-2owmA:
undetectable
5cdqC-2owmA:
undetectable		 5cdqA-2owmA:
22.90
5cdqB-2owmA:
17.12
5cdqC-2owmA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		4 / 5 SER A 106
ARG A  41
GLY A 125
GLU A 127
 ADP  A1002 (-4.7A)
None
None
None
 1.15A 5cdqR-2owmA:
undetectable
5cdqS-2owmA:
undetectable
5cdqT-2owmA:
undetectable		 5cdqR-2owmA:
22.90
5cdqS-2owmA:
17.12
5cdqT-2owmA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		4 / 5 ALA A 115
VAL A 120
LYS A 102
ILE A 389
 None
 0.87A 5of1A-2owmA:
undetectable		 5of1A-2owmA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		5 / 12 ALA A 390
GLY A 149
GLY A 330
LEU A 380
LEU A 329
 None
ADP  A1002 (-3.2A)
None
None
None
 1.11A 5wwsA-2owmA:
undetectable		 5wwsA-2owmA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		6 / 12 VAL A  43
ALA A 387
GLY A 125
ASP A 122
LEU A 163
THR A 153
 None
 1.37A 5yu9D-2owmA:
undetectable		 5yu9D-2owmA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 2owm RELATED TO
KINESIN-LIKE PROTEIN
KIF1C
(Neurospora
crassa) 		4 / 5 ALA A 390
TYR A 143
GLN A 409
ILE A 333
 None
 1.08A 6g9bA-2owmA:
undetectable
6g9bB-2owmA:
undetectable		 6g9bA-2owmA:
13.03
6g9bB-2owmA:
12.04