SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2own'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 8 ALA A  68
GLN A  66
ILE A 115
ILE A 145
 GOL  A 271 (-3.7A)
SO4  A 266 (-3.3A)
None
None
 0.92A 1rg9B-2ownA:
undetectable		 1rg9B-2ownA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		5 / 11 VAL A 212
VAL A 241
GLU A 209
LEU A 187
ILE A 239
 None
 1.34A 1t6zA-2ownA:
undetectable		 1t6zA-2ownA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 8 VAL A 212
VAL A 241
HIS A 166
ASP A 242
 None
None
SO4  A 262 (-4.1A)
None
 0.99A 2ddwA-2ownA:
undetectable		 2ddwA-2ownA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 7 LEU A 238
GLU A 240
ASP A 243
THR A 160
 None
 1.28A 3dzgB-2ownA:
undetectable		 3dzgB-2ownA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 5 ASP A 185
ILE A  34
VAL A 206
THR A 235
 None
 1.10A 3eigA-2ownA:
undetectable		 3eigA-2ownA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		5 / 12 CYH A  22
THR A  29
THR A  32
THR A  31
HIS A  15
 None
 1.47A 3gwxB-2ownA:
undetectable		 3gwxB-2ownA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 5 LEU A  50
ARG A  97
LEU A  48
PRO A 136
 None
UNL  A 268 (-4.1A)
None
None
 1.31A 3onnA-2ownA:
undetectable		 3onnA-2ownA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 5 GLU A 140
GLY A   5
TYR A  96
GLU A  98
 None
 1.29A 3w9tC-2ownA:
undetectable		 3w9tC-2ownA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 5 GLU A 140
GLY A   5
TYR A  96
GLU A  98
 None
 1.30A 3w9tD-2ownA:
undetectable		 3w9tD-2ownA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 8 ALA A  68
GLN A  66
ILE A 115
ILE A 145
 GOL  A 271 (-3.7A)
SO4  A 266 (-3.3A)
None
None
 0.96A 4ndnD-2ownA:
undetectable		 4ndnD-2ownA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		5 / 12 TYR A  96
THR A   3
ALA A   6
ALA A   8
TYR A 111
 None
None
GOL  A 270 (-3.9A)
None
GOL  A 269 ( 3.6A)
 1.27A 4u14A-2ownA:
undetectable		 4u14A-2ownA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		5 / 12 TYR A  96
THR A   3
ALA A   6
ALA A   8
TYR A 111
 None
None
GOL  A 270 (-3.9A)
None
GOL  A 269 ( 3.6A)
 1.29A 4u15A-2ownA:
undetectable		 4u15A-2ownA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		5 / 11 GLU A  21
HIS A  15
VAL A  81
LEU A  33
THR A  32
 None
 1.45A 4ygfB-2ownA:
undetectable		 4ygfB-2ownA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		5 / 11 GLU A  21
HIS A  15
VAL A  81
LEU A  33
THR A  32
 None
 1.37A 4ygfD-2ownA:
undetectable		 4ygfD-2ownA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		5 / 12 GLU A  21
HIS A  15
VAL A  81
LEU A  33
THR A  32
 None
 1.44A 4ygfE-2ownA:
undetectable		 4ygfE-2ownA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		5 / 11 LEU A  30
HIS A 237
TRP A 253
LEU A 191
LEU A 196
 None
 1.17A 4yvpA-2ownA:
undetectable		 4yvpA-2ownA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		5 / 12 LEU A  30
HIS A 237
TRP A 253
LEU A 191
LEU A 196
 None
 1.17A 4yvpB-2ownA:
undetectable		 4yvpB-2ownA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 6 HIS A  15
VAL A  81
LEU A  33
THR A  32
 None
 0.96A 5ogjA-2ownA:
undetectable		 5ogjA-2ownA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 6 HIS A  15
VAL A  81
LEU A  33
THR A  32
 None
 0.96A 5ogjB-2ownA:
undetectable		 5ogjB-2ownA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 5 HIS A  15
VAL A  81
LEU A  33
THR A  32
 None
 0.95A 5ohhA-2ownA:
undetectable		 5ohhA-2ownA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 6 HIS A  15
VAL A  81
LEU A  33
THR A  32
 None
 0.95A 5ohhB-2ownA:
undetectable		 5ohhB-2ownA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 8 ALA A  68
GLN A  66
ILE A 115
ILE A 145
 GOL  A 271 (-3.7A)
SO4  A 266 (-3.3A)
None
None
 0.91A 5t8sA-2ownA:
undetectable		 5t8sA-2ownA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE
(Lactobacillus
plantarum) 		4 / 6 LEU A 225
VAL A 233
THR A 255
LEU A 187
 None
 0.98A 5tudD-2ownA:
undetectable		 5tudD-2ownA:
19.73