SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2owo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 12 LEU A 477
PHE A 475
PHE A 443
LEU A 576
ALA A 503
 None
 1.11A 1bzfA-2owoA:
undetectable		 1bzfA-2owoA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 8 ARG A 242
GLY A 128
ILE A 164
VAL A 170
 None
 0.80A 1d4sB-2owoA:
undetectable		 1d4sB-2owoA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 8 GLU A  76
SER A 132
GLU A 169
GLU A 231
 None
 1.13A 1knyA-2owoA:
undetectable
1knyB-2owoA:
2.1		 1knyA-2owoA:
15.60
1knyB-2owoA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 11 VAL A 121
VAL A 174
GLU A 169
LEU A 130
ILE A 155
 None
 1.37A 1t6zB-2owoA:
undetectable		 1t6zB-2owoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2owo DNA LIGASE
(Escherichia
coli) 		3 / 3 ARG A 366
VAL A 402
GLY A 372
 None
 0.65A 2avvE-2owoA:
undetectable		 2avvE-2owoA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 2owo DNA LIGASE
(Escherichia
coli) 		3 / 3 ARG A  12
VAL A 131
THR A  47
 None
 0.82A 2nmzA-2owoA:
undetectable		 2nmzA-2owoA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 12 LEU A 538
LEU A 535
PHE A 564
ALA A 509
THR A 507
 None
None
None
None
SO4  A 674 ( 4.1A)
 1.12A 2v0mC-2owoA:
undetectable		 2v0mC-2owoA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 7 LEU A 538
LEU A 535
PHE A 508
LEU A 528
 None
 0.99A 2vq5B-2owoA:
undetectable		 2vq5B-2owoA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 8 SER A 254
ILE A 284
LEU A 116
GLY A 286
 None
 0.82A 3dcjB-2owoA:
undetectable		 3dcjB-2owoA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2owo DNA LIGASE
(Escherichia
coli) 		3 / 3 GLU A 536
GLU A 539
TRP A 583
 None
 1.33A 3hrdA-2owoA:
undetectable
3hrdE-2owoA:
undetectable
3hrdF-2owoA:
undetectable		 3hrdA-2owoA:
22.50
3hrdE-2owoA:
22.50
3hrdF-2owoA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 5 LEU A 176
SER A 206
LEU A 220
PRO A 219
 None
 1.24A 3onnA-2owoA:
undetectable		 3onnA-2owoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 12 GLU A 113
LYS A 115
ARG A 136
GLU A 173
VAL A 288
 None
 1.33A 3qwuA-2owoA:
10.3		 3qwuA-2owoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 12 GLU A 113
LYS A 115
GLU A 173
VAL A 288
LYS A 290
 None
 0.97A 3qwuA-2owoA:
10.3		 3qwuA-2owoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 11 GLU A 113
LYS A 115
ARG A 136
GLU A 173
VAL A 288
 None
 1.18A 3qwuB-2owoA:
4.6		 3qwuB-2owoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 11 GLU A 113
LYS A 115
GLU A 173
VAL A 288
LYS A 290
 None
 0.90A 3qwuB-2owoA:
4.6		 3qwuB-2owoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 12 PHE A 443
ILE A 573
LEU A 576
THR A 507
VAL A 581
 None
None
None
SO4  A 674 ( 4.1A)
None
 0.98A 3rukA-2owoA:
undetectable		 3rukA-2owoA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 10 PHE A 443
PHE A 475
ALA A 472
ILE A 573
PHE A 511
 None
 1.50A 3t3qA-2owoA:
undetectable		 3t3qA-2owoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 7 ILE A 573
PHE A 508
HIS A 561
VAL A 552
 None
 0.94A 4a97A-2owoA:
2.9		 4a97A-2owoA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 6 ILE A 573
PHE A 508
HIS A 561
VAL A 552
 None
 0.92A 4a97I-2owoA:
2.5		 4a97I-2owoA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 5 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.81A 4a9jA-2owoA:
undetectable		 4a9jA-2owoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 5 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.82A 4a9jB-2owoA:
undetectable		 4a9jB-2owoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 5 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.87A 4a9jC-2owoA:
undetectable		 4a9jC-2owoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 2owo DNA LIGASE
(Escherichia
coli) 		3 / 3 ARG A  40
ARG A  43
ILE A  73
 None
 0.88A 4b7qA-2owoA:
undetectable		 4b7qA-2owoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 2owo DNA LIGASE
(Escherichia
coli) 		3 / 3 PRO A 550
TYR A 531
GLY A 527
 None
 0.73A 4g2zA-2owoA:
undetectable		 4g2zA-2owoA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 8 ARG A 510
GLN A  72
GLY A 142
THR A 140
 SO4  A 674 (-3.6A)
None
None
SO4  A 674 ( 3.6A)
 1.01A 4k87A-2owoA:
undetectable		 4k87A-2owoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 8 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.91A 4lzrA-2owoA:
undetectable		 4lzrA-2owoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 12 GLU A 328
VAL A 327
PRO A 339
THR A 338
GLY A 335
 None
 1.45A 4ydqB-2owoA:
undetectable		 4ydqB-2owoA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 9 PHE A 532
TYR A 531
VAL A 552
GLY A 553
VAL A 560
 None
 1.28A 5cp4A-2owoA:
undetectable		 5cp4A-2owoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 2owo DNA LIGASE
(Escherichia
coli) 		3 / 3 ASP A 285
ARG A 305
ARG A 136
 None
 0.94A 5eajB-2owoA:
undetectable		 5eajB-2owoA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 12 ALA A 525
LEU A 528
ALA A 529
PHE A 532
THR A 507
 None
None
None
None
SO4  A 674 ( 4.1A)
 1.13A 5k9dA-2owoA:
undetectable		 5k9dA-2owoA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2owo DNA LIGASE
(Escherichia
coli) 		5 / 10 ALA A 202
LEU A 176
GLY A 180
ILE A 123
LEU A 130
 None
 1.00A 5oy01-2owoA:
undetectable
5oy07-2owoA:
undetectable		 5oy01-2owoA:
10.12
5oy07-2owoA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 8 LEU A 512
VAL A 520
VAL A 549
VAL A 552
 None
 1.05A 6cp4A-2owoA:
undetectable		 6cp4A-2owoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 6 VAL A 170
LEU A 235
ARG A 242
HIS A 239
 None
 0.97A 6e43A-2owoA:
undetectable		 6e43A-2owoA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 6 VAL A 170
LEU A 235
ARG A 242
HIS A 239
 None
 0.97A 6e43B-2owoA:
undetectable		 6e43B-2owoA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 6 VAL A 170
LEU A 235
ARG A 242
HIS A 239
 None
 0.99A 6e43C-2owoA:
undetectable		 6e43C-2owoA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2owo DNA LIGASE
(Escherichia
coli) 		4 / 6 VAL A 170
LEU A 235
ARG A 242
HIS A 239
 None
 1.00A 6e43D-2owoA:
2.9		 6e43D-2owoA:
20.88