SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2owp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 2owp HYPOTHETICAL PROTEIN
BXE_B1374
(Paraburkholderia
xenovorans) 		3 / 3 ALA A  10
VAL A  12
TRP A 115
 None
 0.85A 1w5uC-2owpA:
undetectable
1w5uD-2owpA:
undetectable		 1w5uC-2owpA:
7.69
1w5uD-2owpA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2owp HYPOTHETICAL PROTEIN
BXE_B1374
(Paraburkholderia
xenovorans) 		4 / 8 ALA A 120
TYR A  19
ILE A 117
HIS A  37
 None
None
None
EDO  A 137 ( 4.0A)
 0.80A 2zm8A-2owpA:
undetectable		 2zm8A-2owpA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2owp HYPOTHETICAL PROTEIN
BXE_B1374
(Paraburkholderia
xenovorans) 		4 / 8 ALA A 120
TYR A  19
ILE A 117
HIS A  37
 None
None
None
EDO  A 137 ( 4.0A)
 0.81A 2zmaA-2owpA:
undetectable		 2zmaA-2owpA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 2owp HYPOTHETICAL PROTEIN
BXE_B1374
(Paraburkholderia
xenovorans) 		3 / 3 ALA A  10
VAL A  12
TRP A 115
 None
 0.79A 3l8lC-2owpA:
undetectable
3l8lD-2owpA:
undetectable		 3l8lC-2owpA:
7.69
3l8lD-2owpA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2owp HYPOTHETICAL PROTEIN
BXE_B1374
(Paraburkholderia
xenovorans) 		4 / 8 PHE A  91
GLY A 100
LEU A 124
ILE A 125
 None
 0.86A 4em2A-2owpA:
undetectable		 4em2A-2owpA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2owp HYPOTHETICAL PROTEIN
BXE_B1374
(Paraburkholderia
xenovorans) 		4 / 8 ILE A   8
GLN A  11
VAL A  12
THR A 105
 None
 0.75A 6cduD-2owpA:
undetectable
6cduE-2owpA:
undetectable		 6cduD-2owpA:
17.53
6cduE-2owpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2owp HYPOTHETICAL PROTEIN
BXE_B1374
(Paraburkholderia
xenovorans) 		4 / 7 ILE A   8
GLN A  11
VAL A  12
THR A 105
 None
 0.82A 6cduF-2owpA:
undetectable
6cduG-2owpA:
undetectable		 6cduF-2owpA:
17.53
6cduG-2owpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2owp HYPOTHETICAL PROTEIN
BXE_B1374
(Paraburkholderia
xenovorans) 		4 / 8 ILE A   8
GLN A  11
VAL A  12
THR A 105
 None
 0.94A 6cduG-2owpA:
undetectable
6cduH-2owpA:
undetectable		 6cduG-2owpA:
17.53
6cduH-2owpA:
17.53