SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2owy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HBP_A_RTLA184_0 (RETINOL BINDING PROTEIN)	2owy	RECOMBINATION-ASSOCI ATED PROTEIN RDGC (Pseudomonas aeruginosa)	5 / 11	LEU A 223 ALA A 185 VAL A 229 LEU A 214 GLN A 220	None	1.35A	1hbpA-2owyA: 0.8	1hbpA-2owyA: 21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MX1_E_THAE5_2 (LIVER CARBOXYLESTERASE I)	2owy	RECOMBINATION-ASSOCI ATED PROTEIN RDGC (Pseudomonas aeruginosa)	3 / 3	PHE A 294 LEU A 166 LEU A 248	None	0.52A	1mx1E-2owyA: undetectable	1mx1E-2owyA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOU_A_CQAA403_0 (HISTAMINE N-METHYLTRANSFERASE)	2owy	RECOMBINATION-ASSOCI ATED PROTEIN RDGC (Pseudomonas aeruginosa)	4 / 8	ASP A 20 LYS A 24 GLY A 27 PHE A 44	None	1.03A	2aouA-2owyA: undetectable	2aouA-2owyA: 23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OIP_A_MTXA605_1 (CHAIN A, CRYSTAL STRUCTURE OF DHFR)	2owy	RECOMBINATION-ASSOCI ATED PROTEIN RDGC (Pseudomonas aeruginosa)	5 / 12	VAL A 163 LEU A 17 LEU A 158 ILE A 66 LEU A 150	None	1.15A	2oipA-2owyA: undetectable	2oipA-2owyA: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y69_P_CHDP1265_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	2owy	RECOMBINATION-ASSOCI ATED PROTEIN RDGC (Pseudomonas aeruginosa)	4 / 5	PHE A 3 PHE A 286 LEU A 290 PHE A 294	None	1.36A	2y69P-2owyA: undetectable 2y69W-2owyA: undetectable	2y69P-2owyA: 20.38 2y69W-2owyA: 13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UA5_A_06XA501_1 (CYTOCHROME P450 2B6)	2owy	RECOMBINATION-ASSOCI ATED PROTEIN RDGC (Pseudomonas aeruginosa)	4 / 8	ILE A 66 PHE A 44 SER A 160 LEU A 17	None	0.87A	3ua5A-2owyA: undetectable	3ua5A-2owyA: 22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K36_B_SAMB504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	2owy	RECOMBINATION-ASSOCI ATED PROTEIN RDGC (Pseudomonas aeruginosa)	5 / 12	CYH A 195 GLU A 218 GLN A 220 VAL A 191 LEU A 176	None	1.40A	4k36B-2owyA: undetectable	4k36B-2owyA: 22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q0B_A_NVPA901_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	2owy	RECOMBINATION-ASSOCI ATED PROTEIN RDGC (Pseudomonas aeruginosa)	4 / 8	VAL A 250 VAL A 8 TRP A 236 LEU A 240	None	1.07A	4q0bA-2owyA: undetectable	4q0bA-2owyA: 19.75

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HBP_A_RTLA184_0","RETINOL BINDING PROTEIN","2owy","RECOMBINATION-ASSOCIATED PROTEIN RDGC","Pseudomonas aeruginosa",5,"LEU A 223;ALA A 185;VAL A 229;LEU A 214;GLN A 220","None","1.35A","1hbpA-2owyA:0.8","1hbpA-2owyA:21.50"],["1MX1_E_THAE5_2","LIVER CARBOXYLESTERASE I","2owy","RECOMBINATION-ASSOCIATED PROTEIN RDGC","Pseudomonas aeruginosa",3,"PHE A 294;LEU A 166;LEU A 248","None","0.52A","1mx1E-2owyA:undetectable","1mx1E-2owyA:21.80"],["2AOU_A_CQAA403_0","HISTAMINE N-METHYLTRANSFERASE","2owy","RECOMBINATION-ASSOCIATED PROTEIN RDGC","Pseudomonas aeruginosa",4,"ASP A  20;LYS A  24;GLY A  27;PHE A  44","None","1.03A","2aouA-2owyA:undetectable","2aouA-2owyA:23.03"],["2OIP_A_MTXA605_1","CHAIN A, CRYSTAL STRUCTURE OF DHFR","2owy","RECOMBINATION-ASSOCIATED PROTEIN RDGC","Pseudomonas aeruginosa",5,"VAL A 163;LEU A  17;LEU A 158;ILE A  66;LEU A 150","None","1.15A","2oipA-2owyA:undetectable","2oipA-2owyA:21.33"],["2Y69_P_CHDP1265_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","2owy","RECOMBINATION-ASSOCIATED PROTEIN RDGC","Pseudomonas aeruginosa",4,"PHE A   3;PHE A 286;LEU A 290;PHE A 294","None","1.36A","2y69P-2owyA:undetectable;2y69W-2owyA:undetectable","2y69P-2owyA:20.38;2y69W-2owyA:13.64"],["3UA5_A_06XA501_1","CYTOCHROME P450 2B6","2owy","RECOMBINATION-ASSOCIATED PROTEIN RDGC","Pseudomonas aeruginosa",4,"ILE A  66;PHE A  44;SER A 160;LEU A  17","None","0.87A","3ua5A-2owyA:undetectable","3ua5A-2owyA:22.86"],["4K36_B_SAMB504_0","ANAEROBIC SULFATASE-MATURATING ENZYME","2owy","RECOMBINATION-ASSOCIATED PROTEIN RDGC","Pseudomonas aeruginosa",5,"CYH A 195;GLU A 218;GLN A 220;VAL A 191;LEU A 176","None","1.40A","4k36B-2owyA:undetectable","4k36B-2owyA:22.89"],["4Q0B_A_NVPA901_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","2owy","RECOMBINATION-ASSOCIATED PROTEIN RDGC","Pseudomonas aeruginosa",4,"VAL A 250;VAL A   8;TRP A 236;LEU A 240","None","1.07A","4q0bA-2owyA:undetectable","4q0bA-2owyA:19.75"]]