SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2owz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		5 / 12 GLY A 314
GLY A 255
GLY A 254
VAL A 319
ASN A 277
 None
 0.82A 1n2xB-2owzA:
undetectable		 1n2xB-2owzA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		5 / 12 GLY A 157
VAL A 107
LEU A  26
SER A  27
LEU A  77
 None
 0.98A 1ya4C-2owzA:
undetectable		 1ya4C-2owzA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		6 / 12 ALA A  69
ASP A  66
ILE A  40
VAL A 124
ILE A 127
ILE A  36
 None
 1.50A 2rkgA-2owzA:
undetectable		 2rkgA-2owzA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		3 / 3 MET A 279
GLU A  89
ASP A  66
 None
 1.12A 3a25A-2owzA:
undetectable		 3a25A-2owzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 8 ARG A  80
LEU A  73
LEU A 167
ILE A  36
 None
 0.94A 3ln1A-2owzA:
undetectable		 3ln1A-2owzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 7 ARG A  80
LEU A  73
LEU A 167
ILE A  36
 None
 0.94A 3ln1B-2owzA:
undetectable		 3ln1B-2owzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		3 / 3 THR A 236
SER A 237
ARG A 238
 None
 0.81A 3phnA-2owzA:
undetectable		 3phnA-2owzA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 5 LEU A  77
LEU A  73
LEU A  31
SER A  27
 None
 0.95A 3vhuA-2owzA:
undetectable		 3vhuA-2owzA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 5 LEU A 298
PHE A 281
PRO A 278
ALA A 156
 None
 1.49A 3vm4A-2owzA:
undetectable		 3vm4A-2owzA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 8 LYS A  63
ILE A 118
ASN A 117
GLY A 114
 None
None
None
F6P  A 603 ( 3.7A)
 0.69A 3wxoA-2owzA:
undetectable		 3wxoA-2owzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 5 ARG A 249
VAL A 244
LEU A 243
SER A 242
 None
None
F6P  A 603 (-4.3A)
F6P  A 603 ( 4.7A)
 1.26A 4e1gA-2owzA:
undetectable		 4e1gA-2owzA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		5 / 12 LEU A  77
GLU A  93
GLY A  85
PHE A 146
ILE A 130
 None
 1.21A 4hytA-2owzA:
undetectable		 4hytA-2owzA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		5 / 12 LEU A  77
GLU A  93
GLY A  85
PHE A 146
ILE A 130
 None
 1.22A 4hytC-2owzA:
undetectable		 4hytC-2owzA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 8 VAL A 107
VAL A  83
ILE A  82
LEU A  26
 None
 0.80A 4jq1B-2owzA:
undetectable		 4jq1B-2owzA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 6 VAL A 107
VAL A  83
ILE A  82
LEU A  26
 None
 0.90A 4l1wB-2owzA:
undetectable		 4l1wB-2owzA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 7 TYR A 169
GLU A 192
GLU A  14
GLU A  10
 None
 1.29A 4mi4A-2owzA:
undetectable
4mi4C-2owzA:
undetectable		 4mi4A-2owzA:
21.19
4mi4C-2owzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		3 / 3 VAL A 107
ALA A  84
PHE A 146
 None
 0.94A 4w5nA-2owzA:
undetectable		 4w5nA-2owzA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		4 / 6 GLY A 125
THR A 126
SER A 242
VAL A 244
 None
None
F6P  A 603 ( 4.7A)
None
 1.09A 5ewuB-2owzA:
undetectable		 5ewuB-2owzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		5 / 7 ASN A  70
SER A  88
ALA A  87
GLY A  85
VAL A  95
 None
 1.39A 5fpdB-2owzA:
undetectable		 5fpdB-2owzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2owz FRUCTOSE-1,6-BISPHOS
PHATASE
(Escherichia
coli) 		5 / 10 ILE A 118
LEU A  65
PHE A  68
ALA A  33
LEU A  73
 None
 1.24A 5y7pH-2owzA:
undetectable		 5y7pH-2owzA:
22.25