SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ox1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2ox1 3-DEHYDROQUINATE
DEHYDRATASE
(Archaeoglobus
fulgidus) 		4 / 7 GLY A 152
ALA A 124
THR A 103
THR A 158
 None
GOL  A 201 ( 4.8A)
None
None
 0.91A 1c9sT-2ox1A:
undetectable
1c9sU-2ox1A:
undetectable		 1c9sT-2ox1A:
15.54
1c9sU-2ox1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2ox1 3-DEHYDROQUINATE
DEHYDRATASE
(Archaeoglobus
fulgidus) 		3 / 3 CYH A 172
PRO A 177
ASP A 187
 None
 0.87A 3hlwB-2ox1A:
undetectable		 3hlwB-2ox1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 2ox1 3-DEHYDROQUINATE
DEHYDRATASE
(Archaeoglobus
fulgidus) 		5 / 10 MET A  64
ALA A  67
GLU A  23
PHE A  89
LEU A  78
 None
 1.17A 4la0A-2ox1A:
undetectable		 4la0A-2ox1A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 2ox1 3-DEHYDROQUINATE
DEHYDRATASE
(Archaeoglobus
fulgidus) 		5 / 9 MET A  64
ALA A  67
GLU A  23
PHE A  89
LEU A  78
 None
 1.17A 4la0B-2ox1A:
undetectable		 4la0B-2ox1A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 2ox1 3-DEHYDROQUINATE
DEHYDRATASE
(Archaeoglobus
fulgidus) 		3 / 3 CYH A 172
PRO A 177
ASP A 187
 None
 0.84A 4pm5A-2ox1A:
undetectable		 4pm5A-2ox1A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ox1 3-DEHYDROQUINATE
DEHYDRATASE
(Archaeoglobus
fulgidus) 		4 / 8 THR A 158
GLY A 152
ALA A 124
THR A 103
 None
None
GOL  A 201 ( 4.8A)
None
 0.96A 5eevL-2ox1A:
undetectable
5eevV-2ox1A:
undetectable		 5eevL-2ox1A:
15.54
5eevV-2ox1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ox1 3-DEHYDROQUINATE
DEHYDRATASE
(Archaeoglobus
fulgidus) 		4 / 8 THR A 158
GLY A 152
ALA A 124
THR A 103
 None
None
GOL  A 201 ( 4.8A)
None
 0.96A 5eewL-2ox1A:
undetectable
5eewV-2ox1A:
undetectable		 5eewL-2ox1A:
15.54
5eewV-2ox1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ox1 3-DEHYDROQUINATE
DEHYDRATASE
(Archaeoglobus
fulgidus) 		4 / 8 THR A 158
GLY A 152
ALA A 124
THR A 103
 None
None
GOL  A 201 ( 4.8A)
None
 0.96A 5ef3L-2ox1A:
undetectable
5ef3V-2ox1A:
undetectable		 5ef3L-2ox1A:
15.54
5ef3V-2ox1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2ox1 3-DEHYDROQUINATE
DEHYDRATASE
(Archaeoglobus
fulgidus) 		4 / 6 VAL A   4
TYR A 171
ILE A  94
ASP A  77
 None
GOL  A 201 ( 4.5A)
None
None
 1.27A 5iwuA-2ox1A:
undetectable		 5iwuA-2ox1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 2ox1 3-DEHYDROQUINATE
DEHYDRATASE
(Archaeoglobus
fulgidus) 		5 / 12 ASP A  74
ASP A 119
ILE A  93
ASN A  72
SER A  70
 None
 1.08A 6mhtA-2ox1A:
undetectable		 6mhtA-2ox1A:
23.15