SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oxc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20
(Homo
sapiens) 		4 / 7 ARG A 140
LEU A 240
MET A 239
ILE A 229
 None
 0.99A 3gp0A-2oxcA:
undetectable		 3gp0A-2oxcA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20
(Homo
sapiens) 		5 / 12 PHE A  82
ILE A 153
LEU A 121
ASP A 122
PHE A  64
 ADP  A 300 (-4.4A)
None
None
None
None
 1.27A 3ko0A-2oxcA:
undetectable
3ko0B-2oxcA:
undetectable
3ko0C-2oxcA:
undetectable
3ko0D-2oxcA:
undetectable		 3ko0A-2oxcA:
19.37
3ko0B-2oxcA:
19.37
3ko0C-2oxcA:
19.37
3ko0D-2oxcA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20
(Homo
sapiens) 		5 / 12 PHE A  64
PHE A  82
ILE A 153
LEU A 121
ASP A 122
 None
ADP  A 300 (-4.4A)
None
None
None
 1.28A 3ko0G-2oxcA:
undetectable
3ko0H-2oxcA:
undetectable
3ko0I-2oxcA:
undetectable
3ko0J-2oxcA:
undetectable		 3ko0G-2oxcA:
19.37
3ko0H-2oxcA:
19.37
3ko0I-2oxcA:
19.37
3ko0J-2oxcA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20
(Homo
sapiens) 		5 / 11 PHE A  64
LEU A 121
ASP A 122
PHE A  82
ILE A 153
 None
None
None
ADP  A 300 (-4.4A)
None
 1.26A 3ko0A-2oxcA:
undetectable
3ko0B-2oxcA:
undetectable
3ko0I-2oxcA:
undetectable
3ko0J-2oxcA:
undetectable		 3ko0A-2oxcA:
19.37
3ko0B-2oxcA:
19.37
3ko0I-2oxcA:
19.37
3ko0J-2oxcA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20
(Homo
sapiens) 		5 / 10 PHE A  64
PHE A  82
ILE A 153
LEU A 121
ASP A 122
 None
ADP  A 300 (-4.4A)
None
None
None
 1.32A 3m0wC-2oxcA:
undetectable
3m0wD-2oxcA:
undetectable
3m0wE-2oxcA:
undetectable
3m0wF-2oxcA:
undetectable		 3m0wC-2oxcA:
20.69
3m0wD-2oxcA:
20.69
3m0wE-2oxcA:
20.69
3m0wF-2oxcA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20
(Homo
sapiens) 		5 / 10 LEU A 121
ASP A 122
PHE A  82
ILE A 153
PHE A  64
 None
None
ADP  A 300 (-4.4A)
None
None
 1.31A 3m0wE-2oxcA:
undetectable
3m0wF-2oxcA:
undetectable
3m0wG-2oxcA:
undetectable
3m0wH-2oxcA:
undetectable		 3m0wE-2oxcA:
20.69
3m0wF-2oxcA:
20.69
3m0wG-2oxcA:
20.69
3m0wH-2oxcA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20
(Homo
sapiens) 		3 / 3 GLY A 109
GLY A 111
THR A 113
 ADP  A 300 (-3.5A)
ADP  A 300 (-3.2A)
ADP  A 300 (-3.7A)
 0.42A 3si7B-2oxcA:
3.2		 3si7B-2oxcA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20
(Homo
sapiens) 		3 / 3 GLY A 189
PRO A 188
ALA A 137
 None
 0.50A 4qn9B-2oxcA:
undetectable		 4qn9B-2oxcA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20
(Homo
sapiens) 		5 / 9 LEU A 250
ILE A 103
ILE A 226
GLU A 224
GLU A 212
 None
 1.11A 5igzA-2oxcA:
undetectable		 5igzA-2oxcA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20
(Homo
sapiens) 		5 / 12 GLY A 154
GLY A  76
ALA A  79
ILE A 150
LEU A 121
 None
 1.16A 6b3aA-2oxcA:
3.7		 6b3aA-2oxcA:
16.08