SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 9 ASP A  80
ALA A 103
SER A 129
GLY A  84
GLY A  82
SAM  A 300 ( 4.6A)
None
None
SAM  A 300 (-3.5A)
SAM  A 300 (-3.3A)
1.25A 1bcuH-2oxtA:
undetectable
1bcuH-2oxtA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  86
GLY A  87
TRP A  88
LEU A 106
LYS A 184
SAM  A 300 (-3.3A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 4.3A)
0.62A 1eizA-2oxtA:
14.9
1eizA-2oxtA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  86
GLY A  87
TRP A  88
LEU A 106
LYS A 184
SAM  A 300 (-3.3A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 4.3A)
0.65A 1ej0A-2oxtA:
14.7
1ej0A-2oxtA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.18A 1gtnB-2oxtA:
undetectable
1gtnC-2oxtA:
undetectable
1gtnB-2oxtA:
11.76
1gtnC-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.19A 1gtnH-2oxtA:
undetectable
1gtnI-2oxtA:
undetectable
1gtnH-2oxtA:
11.76
1gtnI-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 8 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.20A 1gtnI-2oxtA:
undetectable
1gtnJ-2oxtA:
undetectable
1gtnI-2oxtA:
11.76
1gtnJ-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.24A 1gtnO-2oxtA:
undetectable
1gtnP-2oxtA:
undetectable
1gtnO-2oxtA:
11.76
1gtnP-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 9 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.18A 1gtnQ-2oxtA:
undetectable
1gtnR-2oxtA:
undetectable
1gtnQ-2oxtA:
11.76
1gtnR-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 7 TYR A  28
TRP A  13
TYR A 189
GLY A   6
None
1.28A 1mxgA-2oxtA:
undetectable
1mxgA-2oxtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.15A 1utdT-2oxtA:
undetectable
1utdU-2oxtA:
undetectable
1utdT-2oxtA:
11.76
1utdU-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 GLY A  82
GLY A  84
LEU A 106
ASP A 132
ILE A 133
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.8A)
0.69A 1x1aA-2oxtA:
9.5
1x1aA-2oxtA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 GLY A  82
GLY A  86
TRP A  88
LEU A 106
LYS A 184
SAM  A 300 (-3.3A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 4.3A)
0.66A 2nyuA-2oxtA:
14.7
2nyuA-2oxtA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 GLY A  82
GLY A  86
TRP A  88
LEU A 106
LYS A 184
SAM  A 300 (-3.3A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 4.3A)
0.62A 2nyuB-2oxtA:
14.8
2nyuB-2oxtA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
12 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
LEU A 106
GLU A 112
ILE A 133
HIS A 134
ASP A 147
VAL A 148
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
None
SAM  A 300 (-3.8A)
SAM  A 300 (-4.3A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.2A)
0.02A 2oxtA-2oxtA:
48.9
2oxtA-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
3 / 3 SER A  57
HIS A 111
ASP A 132
SAM  A 300 (-2.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
0.01A 2oxtA-2oxtA:
48.9
2oxtA-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
12 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  86
TRP A  88
THR A 105
LEU A 106
GLU A 112
ILE A 133
HIS A 134
VAL A 148
LYS A 184
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
None
SAM  A 300 (-3.8A)
SAM  A 300 (-4.3A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 4.3A)
0.48A 2oxtB-2oxtA:
46.1
2oxtB-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 5 SER A  57
GLY A  87
HIS A 111
ASP A 132
ASP A 147
SAM  A 300 (-2.6A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.19A 2oxtB-2oxtA:
46.1
2oxtB-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
12 / 12 GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
LEU A 106
GLU A 112
ILE A 133
HIS A 134
ASP A 147
VAL A 148
LYS A 184
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
None
SAM  A 300 (-3.8A)
SAM  A 300 (-4.3A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 4.3A)
0.37A 2oxtC-2oxtA:
45.0
2oxtC-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
7 / 12 GLY A  82
GLY A  86
GLU A 112
HIS A 134
ASP A 147
VAL A 148
LYS A 184
SAM  A 300 (-3.3A)
SAM  A 300 ( 4.6A)
None
SAM  A 300 (-4.3A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 4.3A)
1.11A 2oxtC-2oxtA:
45.0
2oxtC-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 4 SER A  57
GLY A  59
HIS A 111
ASP A 132
SAM  A 300 (-2.6A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
0.31A 2oxtC-2oxtA:
45.0
2oxtC-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 ASP A  80
GLY A  82
GLY A  84
GLY A  86
GLU A 112
HIS A 134
ASP A 147
VAL A 148
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 ( 4.6A)
None
SAM  A 300 (-4.3A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.2A)
1.04A 2oxtD-2oxtA:
45.2
2oxtD-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
12 / 12 GLY A  59
ASP A  80
GLY A  82
GLY A  84
GLY A  87
THR A 105
LEU A 106
HIS A 111
GLU A 112
HIS A 134
ASP A 147
VAL A 148
SAM  A 300 (-3.1A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-4.3A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.2A)
0.50A 2oxtD-2oxtA:
45.2
2oxtD-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  59
HIS A 111
GLU A 112
HIS A 134
ASP A 147
VAL A 148
SAM  A 300 (-3.1A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-4.3A)
SAM  A 300 (-3.9A)
SAM  A 300 (-4.2A)
1.49A 2oxtD-2oxtA:
45.2
2oxtD-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.45A 2oxtD-2oxtA:
45.2
2oxtD-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  87
LEU A 106
HIS A 111
GLU A 112
HIS A 134
VAL A 148
SAM  A 300 (-3.2A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-4.3A)
SAM  A 300 (-4.2A)
1.39A 2oxtD-2oxtA:
45.2
2oxtD-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 4 SER A  57
TRP A  88
ASP A 132
ILE A 133
SAM  A 300 (-2.6A)
SAM  A 300 (-3.8A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.8A)
0.18A 2oxtD-2oxtA:
45.2
2oxtD-2oxtA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.41A 2pxcA-2oxtA:
39.1
2pxcA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.70A 2pxcA-2oxtA:
39.1
2pxcA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.27A 2pxcA-2oxtA:
39.1
2pxcA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
7 / 12 GLY A  59
GLY A  82
GLY A  84
TRP A  88
THR A 105
LEU A 106
ASP A 132
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.9A)
0.34A 2wa2A-2oxtA:
34.9
2wa2A-2oxtA:
53.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
7 / 12 GLY A  82
GLY A  84
TRP A  88
THR A 105
LEU A 106
GLU A 112
ASP A 132
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
None
SAM  A 300 (-3.9A)
0.50A 2wa2A-2oxtA:
34.9
2wa2A-2oxtA:
53.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 SER A  57
GLY A  59
GLY A  82
GLY A  84
TRP A  88
THR A 105
LEU A 106
GLU A 112
ASP A 147
SAM  A 300 (-2.6A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
None
SAM  A 300 (-3.9A)
0.57A 2wa2B-2oxtA:
41.1
2wa2B-2oxtA:
53.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  86
GLY A  87
TRP A  88
LEU A 106
LYS A 184
SAM  A 300 (-3.3A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.2A)
SAM  A 300 ( 4.3A)
0.67A 3douA-2oxtA:
14.5
3douA-2oxtA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
LEU A 106
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.9A)
0.44A 3eluA-2oxtA:
38.9
3eluA-2oxtA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.27A 3eluA-2oxtA:
38.9
3eluA-2oxtA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
LEU A 106
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.9A)
0.39A 3elwA-2oxtA:
39.6
3elwA-2oxtA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.29A 3elwA-2oxtA:
39.6
3elwA-2oxtA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
LEU A 106
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.9A)
0.53A 3embA-2oxtA:
38.9
3embA-2oxtA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.28A 3embA-2oxtA:
38.9
3embA-2oxtA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 GLY A  84
TRP A  88
THR A 105
GLU A 112
ASP A 147
SAM  A 300 (-3.5A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.91A 3embA-2oxtA:
38.9
3embA-2oxtA:
49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
10 / 12 SER A  57
GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
LEU A 106
ASP A 132
ASP A 147
SAM  A 300 (-2.6A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.36A 3gczA-2oxtA:
40.6
3gczA-2oxtA:
49.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 GLY A  82
GLY A  84
GLY A  86
ASP A 132
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.66A 3ihtA-2oxtA:
7.3
3ihtA-2oxtA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 GLY A 263
GLY A  53
LEU A 258
SER A  57
GLU A 118
None
None
None
SAM  A 300 (-2.6A)
None
1.00A 3kkzB-2oxtA:
9.0
3kkzB-2oxtA:
18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.36A 3p97A-2oxtA:
39.5
3p97A-2oxtA:
50.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
0.43A 3p97A-2oxtA:
39.5
3p97A-2oxtA:
50.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 3p97A-2oxtA:
39.5
3p97A-2oxtA:
50.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.51A 3p97C-2oxtA:
39.7
3p97C-2oxtA:
50.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.36A 3p97C-2oxtA:
39.7
3p97C-2oxtA:
50.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 8 GLY A  87
ALA A 103
SER A  89
TYR A  90
SAM  A 300 (-3.2A)
None
None
None
0.83A 3u9hA-2oxtA:
undetectable
3u9hA-2oxtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 8 GLY A  87
ALA A 103
SER A  89
TYR A  90
SAM  A 300 (-3.2A)
None
None
None
0.84A 3u9hB-2oxtA:
undetectable
3u9hB-2oxtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 8 ASP A 142
GLY A  76
VAL A 125
SER A 119
None
0.84A 4acbB-2oxtA:
2.2
4acbC-2oxtA:
undetectable
4acbB-2oxtA:
19.20
4acbC-2oxtA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 SER A  57
GLY A  82
GLY A  86
GLY A  87
TRP A  88
ASP A 132
SAM  A 300 (-2.6A)
SAM  A 300 (-3.3A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-3.9A)
0.81A 4b17A-2oxtA:
13.5
4b17A-2oxtA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 SER A  57
GLY A  82
GLY A  86
GLY A  87
TRP A  88
ASP A 147
SAM  A 300 (-2.6A)
SAM  A 300 (-3.3A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-3.9A)
0.54A 4b17A-2oxtA:
13.5
4b17A-2oxtA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 8 GLY A  87
ALA A 103
SER A  89
TYR A  90
SAM  A 300 (-3.2A)
None
None
None
0.86A 4bjcA-2oxtA:
undetectable
4bjcA-2oxtA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.38A 4ctjA-2oxtA:
39.6
4ctjA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 132
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.62A 4ctjA-2oxtA:
39.6
4ctjA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 4ctjA-2oxtA:
39.6
4ctjA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
0.58A 4ctjC-2oxtA:
39.8
4ctjC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 4ctjC-2oxtA:
39.8
4ctjC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.38A 4ctkA-2oxtA:
39.6
4ctkA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.69A 4ctkA-2oxtA:
39.6
4ctkA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 4ctkA-2oxtA:
39.6
4ctkA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_C_SAMC1263_0
(POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.35A 4ctkC-2oxtA:
39.6
4ctkC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CTK_C_SAMC1263_0
(POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 SER A  57
GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 147
SAM  A 300 (-2.6A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.56A 4ctkC-2oxtA:
39.6
4ctkC-2oxtA:
51.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 7 GLY A  87
ALA A 103
SER A  89
TYR A  90
SAM  A 300 (-3.2A)
None
None
None
0.87A 4hyfA-2oxtA:
undetectable
4hyfA-2oxtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 8 GLY A  87
ALA A 103
SER A  89
TYR A  90
SAM  A 300 (-3.2A)
None
None
None
0.89A 4hyfB-2oxtA:
undetectable
4hyfB-2oxtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 8 GLY A  87
ALA A 103
SER A  89
TYR A  90
SAM  A 300 (-3.2A)
None
None
None
0.84A 4hyfC-2oxtA:
undetectable
4hyfC-2oxtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 GLY A  84
GLY A  86
THR A 105
LEU A 106
ILE A 133
SAM  A 300 (-3.5A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-4.6A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.8A)
0.81A 4n49A-2oxtA:
16.5
4n49A-2oxtA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 SER A  57
ASP A  80
GLY A  82
LEU A 106
ASP A 132
SAM  A 300 (-2.6A)
SAM  A 300 ( 4.6A)
SAM  A 300 (-3.3A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.9A)
1.11A 4pghB-2oxtA:
8.2
4pghB-2oxtA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 6 SER A  57
GLY A  82
ASP A 132
ASP A 147
SAM  A 300 (-2.6A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.84A 4uckB-2oxtA:
9.4
4uckB-2oxtA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
3 / 3 LYS A 173
ARG A 102
VAL A  78
None
0.91A 4x3uA-2oxtA:
undetectable
4x3uB-2oxtA:
undetectable
4x3uA-2oxtA:
16.13
4x3uB-2oxtA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 7 ALA A  92
ARG A  85
GLY A  84
GLU A 112
None
None
SAM  A 300 (-3.5A)
None
0.90A 5bs8A-2oxtA:
undetectable
5bs8C-2oxtA:
undetectable
5bs8D-2oxtA:
undetectable
5bs8A-2oxtA:
20.28
5bs8C-2oxtA:
20.28
5bs8D-2oxtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 7 ALA A  93
ARG A  85
GLY A  84
GLU A 112
None
None
SAM  A 300 (-3.5A)
None
0.86A 5bs8A-2oxtA:
undetectable
5bs8C-2oxtA:
undetectable
5bs8D-2oxtA:
undetectable
5bs8A-2oxtA:
20.28
5bs8C-2oxtA:
20.28
5bs8D-2oxtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 6 ALA A  92
ARG A  85
GLY A  84
GLU A 112
None
None
SAM  A 300 (-3.5A)
None
0.91A 5btgA-2oxtA:
undetectable
5btgB-2oxtA:
undetectable
5btgC-2oxtA:
undetectable
5btgA-2oxtA:
20.28
5btgB-2oxtA:
22.68
5btgC-2oxtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 6 ALA A  93
ARG A  85
GLY A  84
GLU A 112
None
None
SAM  A 300 (-3.5A)
None
0.87A 5btgA-2oxtA:
undetectable
5btgB-2oxtA:
undetectable
5btgC-2oxtA:
undetectable
5btgA-2oxtA:
20.28
5btgB-2oxtA:
22.68
5btgC-2oxtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 7 ALA A  93
ARG A  85
GLY A  84
GLU A 112
None
None
SAM  A 300 (-3.5A)
None
0.91A 5btgA-2oxtA:
undetectable
5btgC-2oxtA:
undetectable
5btgD-2oxtA:
undetectable
5btgA-2oxtA:
20.28
5btgC-2oxtA:
20.28
5btgD-2oxtA:
22.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.39A 5e9qA-2oxtA:
39.4
5e9qA-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
7 / 12 GLY A  59
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.71A 5e9qA-2oxtA:
39.4
5e9qA-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 5e9qA-2oxtA:
39.4
5e9qA-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.31A 5e9qC-2oxtA:
39.9
5e9qC-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.65A 5e9qC-2oxtA:
39.9
5e9qC-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.35A 5e9qC-2oxtA:
39.9
5e9qC-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 5ec8A-2oxtA:
39.4
5ec8A-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 SER A  57
GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 147
SAM  A 300 (-2.6A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
0.29A 5ec8A-2oxtA:
39.4
5ec8A-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 SER A  57
GLY A  59
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 147
SAM  A 300 (-2.6A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.68A 5ec8A-2oxtA:
39.4
5ec8A-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.39A 5ec8C-2oxtA:
39.6
5ec8C-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.35A 5ec8C-2oxtA:
39.6
5ec8C-2oxtA:
51.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.17A 5eeuF-2oxtA:
undetectable
5eeuG-2oxtA:
undetectable
5eeuF-2oxtA:
11.76
5eeuG-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5eeuO-2oxtA:
undetectable
5eeuP-2oxtA:
undetectable
5eeuO-2oxtA:
11.76
5eeuP-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5eeuQ-2oxtA:
undetectable
5eeuR-2oxtA:
undetectable
5eeuQ-2oxtA:
11.76
5eeuR-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.17A 5eevF-2oxtA:
undetectable
5eevG-2oxtA:
undetectable
5eevF-2oxtA:
11.76
5eevG-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5eevO-2oxtA:
undetectable
5eevP-2oxtA:
undetectable
5eevO-2oxtA:
11.76
5eevP-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5eevQ-2oxtA:
undetectable
5eevR-2oxtA:
undetectable
5eevQ-2oxtA:
11.76
5eevR-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.17A 5eewF-2oxtA:
undetectable
5eewG-2oxtA:
undetectable
5eewF-2oxtA:
11.76
5eewG-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5eewO-2oxtA:
undetectable
5eewP-2oxtA:
undetectable
5eewO-2oxtA:
11.76
5eewP-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.18A 5eewQ-2oxtA:
undetectable
5eewR-2oxtA:
undetectable
5eewQ-2oxtA:
11.76
5eewR-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.17A 5eexF-2oxtA:
undetectable
5eexG-2oxtA:
undetectable
5eexF-2oxtA:
11.76
5eexG-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5eexO-2oxtA:
undetectable
5eexP-2oxtA:
undetectable
5eexO-2oxtA:
11.76
5eexP-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.17A 5eeyF-2oxtA:
undetectable
5eeyG-2oxtA:
undetectable
5eeyF-2oxtA:
11.76
5eeyG-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5eeyO-2oxtA:
undetectable
5eeyP-2oxtA:
undetectable
5eeyO-2oxtA:
11.76
5eeyP-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.17A 5eezF-2oxtA:
undetectable
5eezG-2oxtA:
undetectable
5eezF-2oxtA:
11.76
5eezG-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5eezO-2oxtA:
undetectable
5eezP-2oxtA:
undetectable
5eezO-2oxtA:
11.76
5eezP-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.17A 5ef0F-2oxtA:
undetectable
5ef0G-2oxtA:
undetectable
5ef0F-2oxtA:
11.76
5ef0G-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5ef0O-2oxtA:
undetectable
5ef0P-2oxtA:
undetectable
5ef0O-2oxtA:
11.76
5ef0P-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.17A 5ef1F-2oxtA:
undetectable
5ef1G-2oxtA:
undetectable
5ef1F-2oxtA:
11.76
5ef1G-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5ef1O-2oxtA:
undetectable
5ef1P-2oxtA:
undetectable
5ef1O-2oxtA:
11.76
5ef1P-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.18A 5ef2F-2oxtA:
undetectable
5ef2G-2oxtA:
undetectable
5ef2F-2oxtA:
11.76
5ef2G-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5ef2O-2oxtA:
undetectable
5ef2P-2oxtA:
undetectable
5ef2O-2oxtA:
11.76
5ef2P-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
None
None
SAM  A 300 (-3.2A)
None
None
1.18A 5ef3F-2oxtA:
undetectable
5ef3G-2oxtA:
undetectable
5ef3F-2oxtA:
11.76
5ef3G-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 10 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
SAM  A 300 (-3.2A)
None
None
None
None
1.19A 5ef3O-2oxtA:
undetectable
5ef3P-2oxtA:
undetectable
5ef3O-2oxtA:
11.76
5ef3P-2oxtA:
11.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.39A 5ehgA-2oxtA:
39.4
5ehgA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
7 / 12 GLY A  59
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.68A 5ehgA-2oxtA:
39.4
5ehgA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 5ehgA-2oxtA:
39.4
5ehgA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
0.65A 5ehgC-2oxtA:
39.6
5ehgC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.36A 5ehgC-2oxtA:
39.6
5ehgC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.40A 5ehiA-2oxtA:
39.5
5ehiA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 132
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.56A 5ehiA-2oxtA:
39.5
5ehiA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 5ehiA-2oxtA:
39.5
5ehiA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.46A 5ehiC-2oxtA:
39.5
5ehiC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 5ehiC-2oxtA:
39.5
5ehiC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.38A 5eifA-2oxtA:
39.6
5eifA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.70A 5eifA-2oxtA:
39.6
5eifA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 5eifA-2oxtA:
39.6
5eifA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.28A 5eifC-2oxtA:
39.9
5eifC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.69A 5eifC-2oxtA:
39.9
5eifC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.35A 5eifC-2oxtA:
39.9
5eifC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.51A 5eiwA-2oxtA:
39.5
5eiwA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 5eiwA-2oxtA:
39.5
5eiwA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.38A 5eiwC-2oxtA:
39.6
5eiwC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
0.66A 5eiwC-2oxtA:
39.6
5eiwC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.35A 5eiwC-2oxtA:
39.6
5eiwC-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.34A 5ekxA-2oxtA:
39.7
5ekxA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 SER A  57
GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-2.6A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.39A 5ekxA-2oxtA:
39.7
5ekxA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
0.62A 5ekxB-2oxtA:
39.8
5ekxB-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.35A 5ekxB-2oxtA:
39.8
5ekxB-2oxtA:
51.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
3 / 3 ASN A 259
ASP A  49
GLY A  50
None
0.66A 5fctB-2oxtA:
undetectable
5fctB-2oxtA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.51A 5ikmA-2oxtA:
38.9
5ikmA-2oxtA:
49.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.30A 5ikmA-2oxtA:
38.9
5ikmA-2oxtA:
49.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
ASP A 132
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
0.42A 5kqrA-2oxtA:
38.9
5kqrA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
7 / 12 GLY A  59
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
0.79A 5kqrA-2oxtA:
38.9
5kqrA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.40A 5kqsA-2oxtA:
38.6
5kqsA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.33A 5kqsA-2oxtA:
38.6
5kqsA-2oxtA:
51.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
ASP A 132
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
0.37A 5m5bA-2oxtA:
39.0
5m5bA-2oxtA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  59
GLY A  84
GLY A  87
THR A 105
HIS A 111
GLU A 112
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
0.91A 5m5bA-2oxtA:
39.0
5m5bA-2oxtA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_A_SAMA301_0
(NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.44A 5njvA-2oxtA:
39.4
5njvA-2oxtA:
51.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_A_SAMA301_0
(NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.33A 5njvA-2oxtA:
39.4
5njvA-2oxtA:
51.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_B_SAMB301_0
(NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.39A 5njvB-2oxtA:
39.1
5njvB-2oxtA:
51.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_B_SAMB301_0
(NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.35A 5njvB-2oxtA:
39.1
5njvB-2oxtA:
51.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_C_SAMC301_0
(NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
0.78A 5njvC-2oxtA:
38.5
5njvC-2oxtA:
51.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_C_SAMC301_0
(NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.35A 5njvC-2oxtA:
38.5
5njvC-2oxtA:
51.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NJV_D_SAMD301_0
(NS5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.53A 5njvD-2oxtA:
38.7
5njvD-2oxtA:
51.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 5 TYR A  90
VAL A 125
ASP A  80
ALA A 103
None
None
SAM  A 300 ( 4.6A)
None
1.13A 5otrA-2oxtA:
undetectable
5otrA-2oxtA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
3 / 3 ARG A  77
PHE A 181
LEU A  81
None
0.80A 5veuA-2oxtA:
undetectable
5veuA-2oxtA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
HIS A 111
GLU A 112
LYS A 184
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-3.6A)
None
SAM  A 300 ( 4.3A)
0.82A 5vimA-2oxtA:
38.8
5vimA-2oxtA:
52.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 4 SER A  57
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-2.6A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.36A 5vimA-2oxtA:
38.8
5vimA-2oxtA:
52.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
7 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
HIS A 111
LYS A 184
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-3.6A)
SAM  A 300 ( 4.3A)
0.33A 5vimB-2oxtA:
38.7
5vimB-2oxtA:
52.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
7 / 12 GLY A  59
GLY A  84
GLY A  87
TRP A  88
HIS A 111
GLU A 112
LYS A 184
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-3.6A)
None
SAM  A 300 ( 4.3A)
0.75A 5vimB-2oxtA:
38.7
5vimB-2oxtA:
52.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 4 SER A  57
THR A 105
ASP A 132
ASP A 147
SAM  A 300 (-2.6A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.39A 5vimB-2oxtA:
38.7
5vimB-2oxtA:
52.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
4 / 8 GLY A  76
ARG A 226
VAL A 143
ASP A 180
None
0.99A 5vlmA-2oxtA:
undetectable
5vlmA-2oxtA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 ALA A 179
LEU A 169
VAL A  72
TYR A 222
ASP A 147
None
None
None
None
SAM  A 300 (-3.9A)
1.41A 5vlmD-2oxtA:
undetectable
5vlmD-2oxtA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.44A 5wz1A-2oxtA:
39.5
5wz1A-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
0.44A 5wz1A-2oxtA:
39.5
5wz1A-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 132
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
0.53A 5wz1B-2oxtA:
39.4
5wz1B-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.48A 5wz1C-2oxtA:
39.3
5wz1C-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
0.51A 5wz1C-2oxtA:
39.3
5wz1C-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.51A 5wz1D-2oxtA:
39.5
5wz1D-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.47A 5wz1E-2oxtA:
39.4
5wz1E-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
0.52A 5wz1E-2oxtA:
39.4
5wz1E-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.53A 5wz1F-2oxtA:
39.5
5wz1F-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  87
TRP A  88
THR A 105
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.44A 5wz1G-2oxtA:
39.4
5wz1G-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
0.47A 5wz1G-2oxtA:
39.4
5wz1G-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  87
TRP A  88
THR A 105
HIS A 111
GLU A 112
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.56A 5wz1H-2oxtA:
39.4
5wz1H-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_A_SAMA601_0
(NS5 MTASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.43A 5wz2A-2oxtA:
39.4
5wz2A-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_A_SAMA601_0
(NS5 MTASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.29A 5wz2A-2oxtA:
39.4
5wz2A-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_B_SAMB601_0
(NS5 MTASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
9 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
ASP A 132
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
0.45A 5wz2B-2oxtA:
39.5
5wz2B-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_B_SAMB601_0
(NS5 MTASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.30A 5wz2B-2oxtA:
39.5
5wz2B-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_C_SAMC601_0
(NS5 MTASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
8 / 12 GLY A  59
GLY A  82
GLY A  84
GLY A  87
TRP A  88
THR A 105
HIS A 111
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.8A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
SAM  A 300 (-3.9A)
0.40A 5wz2C-2oxtA:
39.3
5wz2C-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_C_SAMC601_0
(NS5 MTASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
7 / 12 GLY A  59
GLY A  84
GLY A  87
THR A 105
HIS A 111
GLU A 112
ASP A 147
SAM  A 300 (-3.1A)
SAM  A 300 (-3.5A)
SAM  A 300 (-3.2A)
SAM  A 300 (-4.6A)
SAM  A 300 (-3.6A)
None
SAM  A 300 (-3.9A)
0.68A 5wz2C-2oxtA:
39.3
5wz2C-2oxtA:
50.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5WZ2_C_SAMC601_0
(NS5 MTASE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
6 / 12 GLY A  82
GLY A  59
GLY A  87
GLY A  84
THR A  60
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.1A)
SAM  A 300 (-3.2A)
SAM  A 300 (-3.5A)
None
SAM  A 300 (-3.9A)
1.31A 5wz2C-2oxtA:
39.3
5wz2C-2oxtA:
50.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 GLY A  82
GLY A  87
LEU A 106
ASP A 132
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
1.08A 5yn6A-2oxtA:
11.0
5yn6A-2oxtA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 GLY A  82
GLY A  87
LEU A 106
ASP A 132
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
1.08A 5yniA-2oxtA:
11.1
5yniA-2oxtA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
5 / 12 GLY A  82
GLY A  87
LEU A 106
ASP A 132
ASP A 147
SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
1.03A 5ynmA-2oxtA:
11.3
5ynmA-2oxtA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
3 / 3 GLU A  40
ASP A  37
PRO A 256
None
0.75A 6berA-2oxtA:
undetectable
6berA-2oxtA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban
virus)
3 / 3 LEU A 260
GLY A 121
PHE A 127
None
0.56A 6exiC-2oxtA:
2.2
6exiC-2oxtA:
14.63