SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 2oyr UPF0341 PROTEIN YHIQ
(Shigella
flexneri) 		5 / 12 GLY A 100
LEU A 126
LEU A 149
LEU A 143
ALA A 107
 SAH  A 301 ( 4.6A)
None
None
None
None
 1.09A 1gseB-2oyrA:
undetectable		 1gseB-2oyrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 2oyr UPF0341 PROTEIN YHIQ
(Shigella
flexneri) 		4 / 8 MET A 115
LEU A 126
ARG A 101
SER A 154
 None
None
SAH  A 301 (-4.4A)
SAH  A 301 (-3.4A)
 1.12A 2qd2A-2oyrA:
2.5		 2qd2A-2oyrA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2oyr UPF0341 PROTEIN YHIQ
(Shigella
flexneri) 		3 / 3 LYS A 218
ILE A  55
PHE A  56
 None
 0.91A 3j7zS-2oyrA:
undetectable
3j7za-2oyrA:
undetectable		 3j7zS-2oyrA:
15.50
3j7za-2oyrA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 2oyr UPF0341 PROTEIN YHIQ
(Shigella
flexneri) 		4 / 5 LEU A 203
SER A 154
LEU A 170
PRO A 172
 None
SAH  A 301 (-3.4A)
None
None
 1.08A 3onnA-2oyrA:
2.9		 3onnA-2oyrA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2oyr UPF0341 PROTEIN YHIQ
(Shigella
flexneri) 		4 / 7 VAL A  92
VAL A 216
LEU A 147
ASP A 102
 None
None
None
SAH  A 301 (-3.4A)
 0.93A 3rgfA-2oyrA:
undetectable		 3rgfA-2oyrA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2oyr UPF0341 PROTEIN YHIQ
(Shigella
flexneri) 		3 / 3 PHE A 104
ASP A 102
ARG A  67
 None
SAH  A 301 (-3.4A)
None
 0.87A 4eahF-2oyrA:
undetectable		 4eahF-2oyrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2oyr UPF0341 PROTEIN YHIQ
(Shigella
flexneri) 		3 / 3 PHE A 104
ASP A 102
ARG A  67
 None
SAH  A 301 (-3.4A)
None
 0.86A 4eahG-2oyrA:
undetectable		 4eahG-2oyrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2oyr UPF0341 PROTEIN YHIQ
(Shigella
flexneri) 		4 / 5 ILE A  55
ARG A 188
ASP A  48
VAL A  36
 None
 1.25A 4nkxC-2oyrA:
undetectable		 4nkxC-2oyrA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2oyr UPF0341 PROTEIN YHIQ
(Shigella
flexneri) 		4 / 5 ILE A  55
ARG A 188
ASP A  48
VAL A  36
 None
 1.24A 4nkxD-2oyrA:
undetectable		 4nkxD-2oyrA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 2oyr UPF0341 PROTEIN YHIQ
(Shigella
flexneri) 		5 / 12 GLU A 138
PHE A 104
ARG A 112
GLY A 141
LEU A 143
 None
 1.22A 5ogcB-2oyrA:
2.2		 5ogcB-2oyrA:
20.31