SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2oys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 2oys HYPOTHETICAL PROTEIN
SP1951
(Streptococcus
pneumoniae) 		5 / 12 VAL A 152
ILE A  84
ILE A 173
ILE A 181
ILE A  82
 None
 1.33A 1r5lA-2oysA:
undetectable		 1r5lA-2oysA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2oys HYPOTHETICAL PROTEIN
SP1951
(Streptococcus
pneumoniae) 		3 / 3 ILE A   6
ILE A  36
THR A  40
 None
 0.50A 1rg7A-2oysA:
2.9		 1rg7A-2oysA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2oys HYPOTHETICAL PROTEIN
SP1951
(Streptococcus
pneumoniae) 		3 / 3 HIS A 150
ASP A 123
ASN A 132
 None
 0.88A 1wg8B-2oysA:
3.6		 1wg8B-2oysA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 2oys HYPOTHETICAL PROTEIN
SP1951
(Streptococcus
pneumoniae) 		4 / 6 SER A  44
ARG A 104
PHE A 101
ILE A 105
 None
 1.05A 2qeiA-2oysA:
undetectable		 2qeiA-2oysA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2oys HYPOTHETICAL PROTEIN
SP1951
(Streptococcus
pneumoniae) 		3 / 3 ARG A 217
GLU A 226
TYR A 193
 None
 0.58A 3k37B-2oysA:
undetectable		 3k37B-2oysA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 2oys HYPOTHETICAL PROTEIN
SP1951
(Streptococcus
pneumoniae) 		3 / 3 ASP A  62
SER A  65
ARG A 104
 None
 0.93A 3loqA-2oysA:
2.1		 3loqA-2oysA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2oys HYPOTHETICAL PROTEIN
SP1951
(Streptococcus
pneumoniae) 		3 / 3 GLU A  55
ASP A  52
ASP A  62
 None
 0.78A 4gc9A-2oysA:
undetectable		 4gc9A-2oysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2oys HYPOTHETICAL PROTEIN
SP1951
(Streptococcus
pneumoniae) 		4 / 7 ILE A 154
VAL A 152
ALA A 169
THR A 170
 None
 0.92A 6cduC-2oysA:
undetectable
6cduD-2oysA:
undetectable		 6cduC-2oysA:
22.62
6cduD-2oysA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2oys HYPOTHETICAL PROTEIN
SP1951
(Streptococcus
pneumoniae) 		4 / 7 ALA A 169
THR A 170
ILE A 154
VAL A 152
 None
 0.94A 6cduF-2oysA:
undetectable
6cduJ-2oysA:
undetectable		 6cduF-2oysA:
22.62
6cduJ-2oysA:
22.62